首页|Effect of sumatriptan on gastric emptying: A crossover study using the BreathID system
Effect of sumatriptan on gastric emptying: A crossover study using the BreathID system
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NETL
NSTL
万方数据
维普
AIM:To determine the effect of oral sumatriptan on gastric emptying using a continuous 13C breath test (BreathID system).METHODS:Ten healthy male volunteers participated in this randomized,2-way crossover study.The subjects fasted overnight and were randomly assigned to receive a test meal (200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg (sumatriptan condition),or the test meal alone (control condition).Gastric emptying was monitored for 4 h after administration of the test meal by the 13C-acetic acid breath test performed continually using the BreathID system.Then,using Oridion Research Software (β version),the time taken for emptying of 50％ of the labeled meal (T1/2) similar to the scintigraphy lag time for 10％emptying of the labeled meal (Tlag),the gastric emptying coefficient (GEC),and the regression-estimated constants (β and κ) were calculated.The statistical significance of any differences in the parameters were analyzed using Wilcoxon's signed-rank test.RESULTS:In the sumatdptan condition,significant differences compared with the control condition were found in T1/2 [median 131.84 min (range,103.13-168.70) vs 120.27 min (89.61-138.25); P =0.0016],Tlag [median 80.085 min (59.23-125.89) vs 61.11 min (39.86-87.05);P =0.0125],and β [median 2.3374 (1.6407-3.8209)vs 2.0847 (1.4755-2.9269); P =0.0284].There were no significant differences in the GEC or κ between the 2 conditions.CONCLUSION:This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.
SumatriptanGastric emptyingBreath testLiquid mealBreathID system
NETL
NSTL
万方数据
维普
