首页|Significance of regenerating islet-derived type Ⅳ gene expression in gastroenterological cancers
Significance of regenerating islet-derived type Ⅳ gene expression in gastroenterological cancers
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The regenerating islet-derived members (Reg),a group of small secretory proteins,which are involved in cell proliferation or differentiation in digestive organs,are upregulated in several gastrointestinal cancers,functioning as trophic or antiapoptotic factors.Regenerating islet-derived type Ⅳ (RegⅣ),a member of the Reg gene family,has been reported to be overexpressed in gastroenterological cancers.RegⅣ overexpression in tumor cells has been associated with carcinogenesis,cell growth,survival and resistance to apoptosis.Cancer tissue expressing RegⅣ is generally associated with more malignant characteristics than that without such expression,and RegⅣ is considered a novel prognostic factor as well as diagnostic marker in some gastroenterological cancers.We previously investigated the expression levels of RegⅣ mRNA of 202 surgical colorectal cancer specimens with quantitative real-time reverse-transcriptase polymerase chain reaction and reported that a higher level of RegⅣ gene expression was a significant independent predictor of colorectal cancer.The biologic functions of RegⅣ protein in cancer tissue,associated with carcinogenesis,antiapoptosis and invasiveness,are being elucidated by molecular investigations using transfection techniques or neutralizing antibodies of RegⅣ,and the feasibility of antibody therapy targeting RegⅣ is being assessed.These studies may lead to novel therapeutic strategies for gastroenterological cancers expressing RegⅣ.This review article summarizes the current information related to biological functions as well as clinical importance of RegⅣ gene to clarify the significance of RegⅣexpression in gastroenterological cancers.
Regenerating islet-derived type Ⅳ proteinGastrointestinal neoplasmsPrognosisEpidermal growth factor receptor/protein kinase B
Masakatsu Numata、Takashi Oshima
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Department of Gastroenterological Surgery, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, Kanagawa 241-0815, Japan
Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa 232-0024, Japan
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