首页|Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability
Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability
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NETL
NSTL
万方数据
维普
AIM:To investigate endoscopic and clinicopathologic characteristics of early gastric cancer (EGC) according to microsatellite instability phenotype.METHODS:Data were retrospectively collected from a single tertiary referral center.Of 981 EGC patients surgically treated between December 2003 and October 2007,73 consecutive EGC patients with two or more microsatellite instability (MSI) mutation [high MSI (MSI-H)] and 146 consecutive EGC patients with one or no MSI mutation (non-MSI-H) were selected.The endoscopic and clinicopathologic features were compared between the MSI-H and non-MSI-H EGC groups.RESULTS:In terms of endoscopic characteristics,MSI-H EGCs more frequently presented with elevated pattern (OR 4.38,95％ CI:2.40-8.01,P ＜ 0.001),moderate-to-severe atrophy in the surrounding mucosa (OR 1.91,95％ CI:1.05-3.47,P =0.033),antral location (OR 3.99,95％ CI:2.12-7.52,P ＜ 0.001) and synchronous lesions,compared to non-MSI-H EGCs (OR 2.65,95％ CI:1.16-6.07,P =0.021).Other significant clinicopathologic characteristics of MSI-H EGC included predominance of female sex (OR 2.77,95％ CI:1.53-4.99,P ＜ 0.001),older age (＞ 70 years) (OR 3.30,95％ CI:1.57-6.92,P =0.002),better histologic differentiation (OR 2.35,95％ CI:1.27-4.34,P =0.007),intestinal type by Lauren classification (OR 2.34,95％ CI:1.15-4.76,P =0.019),absence of a signet ring cell component (OR2.44,95％ CI:1.02-5.86,P =0.046),presence of mucinous component (OR 5.06,95％ CI:1.27-20.17,P =0.022),moderate-to-severe lymphoid stromal reaction (OR 3.95,95％ CI:1.59-9.80,P =0.003),and co-existing underlying adenoma (OR 2.66,95％ CI:1.43-4.95,P =0.002).CONCLUSION:MSI-H EGC is associated with unique endoscopic and clinicopathologic characteristics including frequent presentation in protruded type,co-existing underlying adenoma,and synchronous lesions.
Microsatellite instabilityEarly gastric cancerEndoscopic characteristicAdvanced gastric cancer
NETL
NSTL
万方数据
维普
