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Current knowledge on esophageal atresia

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Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is the most common congenital anomaly of the esophagus.The improvement of survival observed over the previous two decades is multifactorial and largely attributable to advances in neonatal intensive care,neonatal anesthesia,ventilatory and nutritional support,antibiotics,early surgical intervention,surgical materials and techniques.Indeed,mortality is currently limited to those cases with coexisting severe life-threatening anomalies.The diagnosis of EA is most commonly made during the first 24 h of life but may occur either antenatally or may be delayed.The primary surgical correction for EA and TEF is the best option in the absence of severe malformations.There is no ideal replacement for the esophagus and the optimal surgical treatment for patients with long-gap EA is still controversial.The primary complications during the postoperative period are leak and stenosis of the anastomosis,gastro-esophageal reflux,esophageal dysmotility,fistula recurrence,respiratory disorders and deformities of the thoracic wall.Data regarding long-term outcomes and follow-ups are limited for patients following EA/TEF repair.The determination of the risk factors for the complicated evolution following EA/TEF repair may positively impact long-term prognoses.Much remains to be studied regarding this condition.This manuscript provides a literature review of the current knowledge regarding EA.

Esophageal atresiaTracheoesophageal fistulaEsophageal stenosisLong-gapGastro-esophageal reflux

Paulo Fernando Martins Pinheiro、Ana Cristina Sim(o)es e Silva、Regina Maria Pereira

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Department of Pediatric Surgery, Odilon Behrens Hospital, Avenida José Bonifácio, S(a)o Cristov(a)o, Belo Horizonte, 31210-690 Minas Gerais, Brazil

Department of Pediatrics, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte,30130-100 Minas Gerais, Brazil

Funda(c)(a)o de Amparo (è) Pesquisa do Estado de Minas Gerais,BrazilConselho Nacional de Desenvolvimento Cientifico e Tecnológico,BrazilPrograma de Grupos de Excel(e)ncia FINEP,Brazil

CBB-APQ-00075-09/CNPq 573646/2008-2

2012

10.3748/wjg.v18.i28.3662

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(28)
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