首页|Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers

Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers

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  • NETL
  • NSTL
  • 万方数据
  • 维普
Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo.Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies.

OsteopontinGastrointestinal cancerMetastasisPrognosisBiomarker

Dong-Xing Cao、Zhi-Jie Li、Xiao-Ou Jiang、Yick Liang Lum、Ester Khin、Nikki P Lee、Guo-Hao Wu、John M Luk

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Department of Pharmacology and Department of Surgery, National University Health System, National University of Singapore, Singapore 117597, Singapore

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032,China

Department of Oncology, Roche R and D Center(China)Ltd., Shanghai 201203, China

Department of Surgery, The University of Hong Kong, Hong Kong, China

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2012

10.3748/wjg.v18.i30.3923

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(30)
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