首页|Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening: A meta-analysis

Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening: A meta-analysis

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AIM:To present a critical discussion of the efficacy of the faecal pyruvate kinase isoenzyme type M2 (faecal M2-PK) test for colorectal cancer (CRC) screening based on the currently available studies.METHODS:A literature search in PubMed and Embase was conducted using the following search terms:fecal Tumor M2-PK,faecal Tumour M2-PK,fecal M2-PK,faecal M2-PK,fecal pyruvate kinase,faecal pyruvate kinase,pyruvate kinase stool and M2-PK stool.RESULTS:Stool samples from 704 patients with CRC and from 11 412 healthy subjects have been investigated for faecal M2-PK concentrations in seventeen independent studies.The mean faecal M2-PK sensitivity was 80.3％; the specificity was 95.2％.Four studies compared faecal M2-PK head-to-head with guaiacbased faecal occult blood test (gFOBT).Faecal M2-PK demonstrated a sensitivity of 81.1％,whereas the gFOBT detected only 36.9％ of the CRCs.Eight independent studies investigated the sensitivity of faecal M2-PK for adenoma (n =554),with the following sensitivities:adenoma ＜ 1 cm in diameter:25％; adenoma ＞ 1 cm:44％; adenoma of unspecified diameter:51％.In a direct comparison with gFOBT of adenoma ＞ 1 cm in diameter,47％ tested positive with the faecal M2-PK test,whereas the gFOBT detected only 27％.CONCLUSION:We recommend faecal M2-PK as a routine test for CRC screening.Faecal M2-PK closes a gap in clinical practice because it detects bleeding and nonbleeding tumors and adenoma with high sensitivity and specificity.

Faecal pyruvate kinase isoenzyme type M2Colorectal cancer screeningColorectal cancerStoolFaecal occult bloodAdenomaPolyps

Carolin Tonus、Markus Sellinger、Konrad Koss、Gero Neupert

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Asklepios Hospital North, General and Visceral Surgery, 22417 Hamburg, Germany

Medical Practice for Gastroenterology Lusanum, 67061 Ludwigshafen, Germany

Department of Gastroenterology, Macclesfield District General Hospital, Macclesfield, Cheshire SK10 3BL,United Kingdom

2012

10.3748/wjg.v18.i30.4004

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(30)
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