首页|Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome

Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome

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AIM:To assess the symptomatic efficacy of Lactobacillus plantarum 299v (L.plantarum 299v) (DSM 9843) for the relief of abdominal symptoms in a large subset of irritable bowel syndrome (IBS) patients fulfilling the Rome Ⅲ criteria.METHODS:In this double blind,placebo-controlled,parallel-designed study,subjects were randomized to daily receive either one capsule of L.plantarum 299v (DSM 9843) or placebo for 4 wk.Frequency and intensity of abdominal pain,bloating and feeling of incomplete rectal emptying were assessed weekly on a visual analogue scale while stool frequency was calculated.RESULTS:Two hundred and fourteen IBS patients were recruited.After 4 wk,both pain severity (0.68+ 0.53 vs 0.92 + 0.57,P ＜ 0.05) and daily frequency (1.01 + 0.77 vs 1.71 + 0.93,P ＜ 0.05) were lower with L.plantarum 299v (DSM 9843) than with placebo.Similar results were obtained for bloating.At week 4,78.1％ of the patients scored the L.plantarum 299v (DSM 9843) symptomatic effect as excellent or good vs only 8.1％ for placebo (P ＜ 0.01).CONCLUSION:A 4-wk treatment with L.plantarum 299v (DSM 9843) provided effective symptom relief,particularly of abdominal pain and bloating,in IBS patients fulfilling the Rome Ⅲ criteria.

Irritable bowel syndromeProbioticsLactobacillus plantarum 299vClinical trialAbdominal pain

Philippe Ducrotté、Prabha Sawant、Venkataraman Jayanthi

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Department of Gastroenterology(Inserm UMR-1073), Rouen University Hospital and Rouen University,76031 Rouen Cedex, France

Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Mumbai 400022, India

Department of Gastroenterology, Gov Stanley Hospital, Chennai 600108, India

2012

10.3748/wjg.v18.i30.4012

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(30)
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