首页|Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy
Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy
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AIM:To investigate the relationship between the function of vagus nerve and peptide YY3-36 and ghrelin levels after subtotal gastrectomy,METHODS:We enrolled a total of 16 patients who underwent subtotal gastrectomy due to gastric cancer.All surgeries were performed by a single skilled surgeon.We measured peptide YY3-36,ghrelin,leptin,insulin,growth hormone levels,and body weight immediately before and one month after surgery.RESULTS:Vagus nerve preservation group showed less body weight loss and less increase of peptide YY3-36 compared with vagotomy group (-5.56 ± 2.24 kg vs -7.85 ± 1.57 kg,P =0.037 and 0.06 ± 0.08 ng/mL vs 0.19±0.12 ng/mL,P =0.021,respectively).Moreover,patients with body weight loss of less than 10％ exhibited reduced elevation of peptide YY3-36 level,typically less than 20％ [6 (66.7％) vs 0 (0.0％),P =0.011,odd ratio =3.333,95％ confidence interval (1.293,8.591)].CONCLUSION:Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy,and this phenomenon may be related to the suppressed activity of peptide YY3-36.
Peptide YYGhrelinVagotomyGastrectomyBody weight
Hyung Hun Kim、Moo In Park、Sang Ho Lee、Hyun Yong Hwang、Sung Eun Kim、Seun Ja Park、Won Moon
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Departments of Internal Medicine, Kosin University College of Medicine, Busan 602-702, South Korea
Departments of Surgery, Kosin University College of Medicine, Busan 602-702, South Korea
Departments of Laboratory Medicine, Kosin University College of Medicine, Busan 602-702, South Korea
NETL
NSTL
万方数据
维普
