首页|Alginate controls heartburn in patients with erosive and nonerosive reflux disease
Alginate controls heartburn in patients with erosive and nonerosive reflux disease
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NETL
NSTL
万方数据
维普
AIM:To evaluate the effect of a novel alginate-based compound,Faringel,in modifying reflux characteristics and controlling symptoms.METHODS:In this prospective,open-label study,40 patients reporting heartburn and regurgitation with proven reflux disease (i.e.,positive impedance-pH test/evidence of erosive esophagitis at upper endoscopy) underwent 2 h impedance-pH testing after eating a refluxogenic meal.They were studied for 1 h under basal conditions and 1 h after taking 10 mL Faringel.In both sessions,measurements were obtained in right lateral and supine decubitus positions.Patients also completed a validated questionnaire consisting of a 2-item 5-point (0-4) Likert scale and a 10-cm visual analogue scale (VAS) in order to evaluate the efficacy of Faringel in symptom relief.Tolerability of the treatment was assessed using a 6-point Likert scale ranging from very good (1) to very poor (6).RESULTS:Faringel decreased significantly (P ＜ 0.001),in both the right lateral and supine decubitus positions,esophageal acid exposure time [median 10 (25th-75th percentil 6-16) vs 5.8 (4-10) and 16 (11-19) vs 7.5 (5-11),respectively] and acid refluxes [5 (3-8) vs 1 (1-1) and 6 (4-8) vs 2 (1-2),respectively],but increased significantly (P ＜ 0.01) the number of nonacid reflux events compared with baseline [2 (1-3) vs 3 (2-5) and 3 (2-4) vs 6 (3-8),respectively].Percentage of proximal migration decreased in both decubitus positions (60％ vs 32％ and 64％ vs 35％,respectively; P ＜ 0.001).Faringel was significantly effective in controlling heartburn,based on both the Likert scale [3.1(range 1-4) vs 0.9 (0-2); P ＜ 0.001] and VAS score [7.1 (3-9.8) vs 2 (0.1-4.8); P ＜ 0.001],but it had less success against regurgitation,based on both the Likert scale [2.6 (1-4) vs 2.2 (1-4); P =not significant (NS)]and VAS score [5.6 (2-9.6) vs 3.9 (1-8.8); P =NS].Overall,the tolerability of Faringel was very good 5(2-6),with only two patients reporting modest adverse events (i.e.,nausea and bloating).CONCLUSION:Our findings demonstrate that Faringel is well-tolerated and effective in reducing heartburn by modifying esophageal acid exposure time,number of acid refluxes and their proximal migration.
NETL
NSTL
万方数据
维普
