首页|Opposite fates of fructose in the development of metabolic syndrome

Opposite fates of fructose in the development of metabolic syndrome

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
This short review comments on the recently published work of Ishimoto et al regarding the opposing effects of fructokinase C and A isoforms on fructoseinduced metabolic syndrome in mice.The framework for the commentary is the preexisting background of epidemiological and experimental data regarding the association between ingestion of fructose,as present in sweetened beverages,and the development of metabolic syndrome.The work of Ishimoto etal clearly confirms the negative effect of fructose on lipid and glucose metabolism,independently from the amount of energy provided by the ingested sugar.It also confirms the absolute requirement of liver fructose metabolism,driven by fructokinase activity,in order to develop the full spectrum of metabolic syndrome alterations.

Lipid metabolismFatty liverObesityHyperglycemiaDyslipidemia

Marta Alegret、Juan C Laguna

展开 >

Department of Pharmacology and Therapeutic Chemistry, School of Pharmacy, University of Barcelona, Institute of Biomedicine, 08028 Barcelona, Spain

Biomedical Network Research Centre, Physiopathology of Obesity and Nutrition(CIBERobn),08028 Barcelona, Spain

2012

10.3748/wjg.v18.i33.4478

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(33)
  • 16