首页|Entry of hepatitis C virus into the cell: A therapeutic target
Entry of hepatitis C virus into the cell: A therapeutic target
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
维普
Several receptors have been identified as implicated on viral entry into the hepatocyte; and,this interaction between the virus and potential receptors could modulate infection,spontaneous viral clearance,persistence of the infection and the widespread of the virus as outbreak.Nevertheless,the playing role of each of them remains controversial.The NiemannPick type C1 like 1 gene (NPC1L1) receptor has been recently implicated on hepatitis C virus (HCV) entry into the cell and ezetimibe,an anti-cholesterol drug seems to block that,emerging the idea to control hepatitis C outbreak modulating lipid-related receptors.Hepatitis C infection seems to modulate lipid metabolism according to host genetic background.Indeed,it circulates like a lipoviroparticle.The main aim of this field of vision would be to discuss the role of hepatocyte receptors implicated on virus entry,especially NPC1L1 and the therapeutic options derived from the better knowledge about HCV-lipids-receptors interaction.
Hepatitis C virus entryNiemann-Pick type C1 like 1 geneLipid metabolismEzetimibe
José Antonio Del Campo、(A)ngela Rojas、Manuel Romero-Gómez
展开 >
Unit for Medical and Surgical Management of Digestive Diseases, Center for Biomedical Research in Digestive and Liver Diseases Network(CIBERehd), Valme University Hospital, University of Seville, E-41014 Sevilla, Spain
NETL
NSTL
万方数据
维普
