首页|Gastric mucin expression in Helicobacter pylori-related,nonsteroidal anti-inflammatory drug-related and idiopathic ulcers

Gastric mucin expression in Helicobacter pylori-related,nonsteroidal anti-inflammatory drug-related and idiopathic ulcers

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AIM:To determine the pattern of secreted mucin expression in Helicobacter pylori (H.pylori)-related,nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers.METHODS:We randomly selected 92 patients with H.pylori-associated (n =30),NSAID-associated (n =18),combined H.pylori and NSAID-associated gastric ulcers (n =24),and patients with idiopathic gastric ulcers (n =20).Immunohistochemistry for T-cell CD4/CD8,and for mucin 5AC (MUC5AC) and mucin 6 (MUC6),was performed on sections of the mucosa from the ulcer margin.Inflammation score was assessed according to the Sydney system.RESULTS:MUC5AC was expressed on the surface epithelium (98.9％) and neck glands (98.9％) with minimal expression in the deep glands (6.5％).MUC6 was strongly expressed in the deep glands (97.8％),variable in the neck glands (19.6％) and absent in the surface epithelium (0％).The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H.pylori,NSAIDs,or combined H.pylori and NSAIDs.CD4/CD8 ratio was higher in H.pylori-positive patients (P =0.009).Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates.CONCLUSION:Idiopathic ulcers have a unique clinical profile.Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H.pylori and/or NSAID-associated ulcers.

Idiopathic ulcerMucinMucin 5ACMucin 6Helicobacter pylori

Doron Boltin、Marisa Halpern、Zohar Levi、Alex Vilkin、Sara Morgenstern、Samuel B Ho、Yaron Niv

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Department of Gastroenterology, Rabin Medical Center, Tel Aviv University, Petah Tikva 49100, Israel

Department of Pathology, Rabin Medical Center, Hasharon Hospital, Petah Tikva 49100, Israel

Department of Pathology, Rabin Medical Center, Beilinson Hospital, Petah Tikva 49100, Israel

Department of Medicine, University of California, and VA San Diego Healthcare System, San Diego, CA 92161, United States

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2012

10.3748/wjg.v18.i33.4597

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(33)
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