首页|Clinicopathologic significance of expression of nuclear factor-κB RelA and its target gene products in gastric cancer patients
Clinicopathologic significance of expression of nuclear factor-κB RelA and its target gene products in gastric cancer patients
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NETL
NSTL
万方数据
维普
AIM:To assess the prognostic significance of nuclear factor-κB (NF-κB) and its target genes in gastric cancer.METHODS:The tumor tissues of 115 patients with gastric cancer were immunohistochemically evaluated using monoclonal antibodies against NF-κB RelA.Preoperative serum levels of vascular endothelial growth factor (VEGF),interleukin-6 (IL-6) were assessed via enzyme-linked immuno-sorbent assay.C-reactive protein (CRP) and serum amyloid A (SAA) were measured via immunotrubidimetry.RESULTS:Positive rate of NF-κB RelA was 42.6％.NF-κB RelA expression in tumor tissues was also related to serum levels of IL-6 (P =0.044) and CRP (P =0.010).IL-6,SAA,CRP were related to depth of invasion,VEGF and SAA were correlated with lymph node metastasis.IL-6,VEGF,SAA and CRP were related to the stage.Univariate analysis demonstrated that immunostaining of NF-κB RelA,levels of IL-6,VEGF,SAA were significantly related with both disease free survival and overall survival (OS).Multivariate analysis verified that NF-κB RelA [hazard ratio (HR):3.40,P =0.024] and SAA (HR:3.39,P =0.045) were independently associated with OS.CONCLUSION:Increased expression of NF-κB RelA and high levels of serum SAA were associated with poor OS in gastric cancer patients.
NETL
NSTL
万方数据
维普
