首页|Prognosis of hepatocellular carcinoma expressing cytokeratin 19: Comparison with other liver cancers
Prognosis of hepatocellular carcinoma expressing cytokeratin 19: Comparison with other liver cancers
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
维普
AIM:To investigate whether expressing biliary phenotype predicted poor outcome after the surgical treatment in primary liver cancers.METHODS:Out of 204 patients that underwent liver resection due to hepatocellular carcinoma (HCC),liver specimens of 70 patients with HCC were evaluated for biliary components by cytokeratin (CK) 19 immunostain (CK19-HCC and CK19+ HCC).CK19 positivity was defined as membranous and/or cytoplasmic expression in ≥ 5％ of tumor cells with moderate or strong intensity.Patients with other primary liver cancers,such as combined HCC and cholangiocarcinoma (cHCC-CC),intrahepatic cholangiocarcinoma (ICC) who received curative liver resection,were also included in the study.Clinical characteristics of CK19 HCC and CK19+ HCC patients,including survival outcome after curative liver resection,were compared with that of cHCC-CC and ICC patients.RESULTS:The overall survival (OS) rate of CK19 HCC (n =49) after the curative surgical treatment was 90.7％,and 80.4％ at 1 and 5 years after the resection.OS rate of CK19+ HCC (n =21) was 74.3％,28.9％ and OS rate of cHCC-CC (n =22) was 66.7％,32.2％ at 1 and 5 years after the surgery.For ICC (n =19),1 and 5-year-OS rate was 50.2％ and 14.3％ after the curative resection.The OS rates of CK19+ HCC and cHCC-CC were significantly lower than that of CK19 HCC,but higher than the OS rate of IcC (P =0.000).There was no statistically significant difference in OS rate between CK19+ HCC and cHCC-CC.The disease free survival (DFS) rate of CK19 HCC was 72.0％ and 54.5％ at 1 and 3 years after the surgical treatment.DFS rate of CK19+ HCC was 53.3％,34.3％ and DFS rate of cHCC-CC was 51.5％,39.2％ at I and 3 years after the resection.For ICC,1 and 3-year-DFS rate was 28.0％ and 14.0％ after the curative resection.DFS rate of CK19 HCC was significantly higher than that of ICC (P =0.017),but marginally higher than DFS rate of either CK19+ HCC or cHCC-CC (P =0.097,P =0.089,respectively).Predictors of outcome after the surgery of primary liver cancer were pathology of the resected mass,existence of microvascular invasion and accompanying satellite nodule.CONCLUSION:Primary liver cancers with biliary components tended to show poorer surgical outcome.This suggested that immuno-phenotype of liver cancers was as important as their morphological classification.
NETL
NSTL
万方数据
维普
