首页|Role for mycobacterial infection in pathogenesis of primary biliary cirrhosis?

Role for mycobacterial infection in pathogenesis of primary biliary cirrhosis?

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized by the immunemediated destruction of biliary epithelial cells in small intrahepatic bile ducts.The disease is characterized by circulating antimitochondrial antibodies (AMAs) as well as disease-specific antinuclear antibodies,cholestatic liver function tests,and characteristic histological features,including granulomas.A variety of organisms are involved in granuloma formation,of which mycobacteria are the most commonly associated.This has led to the hypothesis that mycobacteria may be involved in the pathogenesis of PBC,along with other infectious agents.Additionally,AMAs are found in a subgroup of patients with mycobacterial infections,such as leprosy and pulmonary tuberculosis.Antibodies against species-specific mycobacterial proteins have been reported in patients with PBC,but it is not clear whether these antibodies are specific for the disease.In addition,data in support of the involvement of the role of molecular mimicry between mycobacterial and human mitochondrial antigens as triggers of cross-reactive immune responses leading to the loss of immunological tolerance,and the induction of pathological features have been published.Thus,antibodies against mycobacterial heat shock protein appear to cross-recognize AMA-specific autoantigens,but it is not clear whether these autoantibodies are mycobacterium-species-specific,and whether they are pathogenic or incidental.The view that mycobacteria are infectious triggers of PBC is intriguing,but the data provided so far are not conclusive.

Antimitochondrial antibodiesAutoantibodyAutoimmunityCholestasisHeat shockInfectionLiver diseaseLiver failureMycobacteriumTuberculosis

Daniel Smyk、Eirini I Rigopoulou、Yoh Zen、Robin Daniel Abeles、Charalambos Billinis、Albert Pares、Dimitrios P Bogdanos

展开 >

Institute of Liver Studies and Liver Unit, King's College London School of Medicine at King's College Hospital and Kings College Hospital NHS Trust Foundation Trust, London SE5 9RS, United Kingdom

Department of Medicine, University Hospital of Larissa, University of Thessaly Medical School, Biopolis, Larissa 41110, Greece

Institute of Biomedical Research and Technology(BIOMED), CERETETH, Larissa 41222, Greece

Faculty of Veterinary Medicine, University of Thessaly, Karditsa 43100, Greece

Liver Unit, Digestive Diseases Institute, Hospital Clinic, IDIBAPS, CIBEREHD, University of Barcelona, Barcelona 08036, Spain

展开 >

2012

10.3748/wjg.v18.i35.4855

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(35)
  • 1
  • 142