首页|Inducible nitric oxide synthetase genotype and Helicobacter pylori infection affect gastric cancer risk

Inducible nitric oxide synthetase genotype and Helicobacter pylori infection affect gastric cancer risk

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AIM:To investigate the association of the inducible nitric oxide synthetase (iNOS) C150T polymorphism with Helicobacter pylori (H.pylorl) infection and gastric cancer (GC) risk in Iran.METHODS:In order to determine whether there was a correlation between iNOS genotype and GC in Iran,we conducted a case-control study using samples from 329 individuals.For each sample,the C150T iNOS polymorphism was genotyped by polymerase chain reaction (PCR) and restriction digestion.Patients were grouped by cancer presence,demographic and behavior characteristics,and H.pylori infection status.Statistical tests were conducted to determine whether any behavioral factors or a particular iNOS genotype was associated with GC in the study population.RESULTS:In this population,we found that smoking,hot beverage consumption,a familial history of GC and H.pylori infection status were significantly associated with GC development (P =0.015,P ＜ 0.001,P =0.0034,and P ＜ 0.015,respectively).The distribution of the C150T iNOS genotypes among the two study groups was not statistically significant alone,but was impacted by H.pylori infection status.When compared to the non-H,pylori infected group,cancer patients who had a heterozygous CT genotype and were also infected with H.pylori were 2.1 times more at risk of developing GC [odds ratio (OR) =2.1,P =0.03] while those with a homozygous （TT） genotype and infected with H.pylori were 5.0 times more at risk of developing GC (OR =5.0,P =0.029).In contrast,this association was not seen in patients in the control group.CONCLUSION:A CT or TT polymorphism at position 150 in the iNOS gene significantly increases the risk of GC and may be a marker for GC susceptibility.

Inducible nitric oxide synthetaseGastric cancerHelicobacter pyloriHeterozygous CT genotypeHomozygous (TT) genotype

Alireza Rafiei、Vahid Hosseini、Ghasern Janbabai、Bahman Fazli、Abulghasem Ajami、Zahra Hosseini-khah、Jeremy J Gilbreath

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Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences,Sari 48175-1665, Iran

Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari 48175-1665, Iran

Department of Internal Medicine, Imam Hospital, Mazandaran University of Medical Sciences, Sari 48175-1665, Iran

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States

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Mazandaran University of Medical Sciences

88-512

2012

10.3748/wjg.v18.i35.4917

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(35)
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