首页|Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases

Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases

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AIM:To assess clinical and endoscopic response to propionyl-L-carnitine hydrochloride (PLC) in colonic inflammatory bowel disease.METHODS:Patients suffering from mild to moderate ulcerative colitis (UC) or Crohn's disease (CD) colitis,with disease activity index (DAI) between 3 and 10 and under stable therapy with oral aminosalicylates,mercaptopurine or azathioprine,for at least 8 wk prior to baseline assessments,were considered suitable for enrollment.Fourteen patients were enrolled to assume PLC 2 g/d (two active tablets twice daily) orally.Clinical-endoscopic and histological activity were assessed by DAI and histological index (HI),respectively,following a colonoscopy performed immediately before and after 4 wk treatment.Clinical response was defined as a lowering of at least 3 points in DAI and clinical remission as a DAI score ≤ 2.Histological response was defined as an improvement of HI of at least 1 point.We used median values for the analysis.Differences pre-and post-treatment were analyzed by Wilcoxon signed rank test.RESULTS:All patients enrolled completed the study.One patient,despite medical advice,took deflazacort 5 d before follow-up colonoscopy examination.No side effects were reported by patients during the trial.After treatment,71％ (SE 12％) of patients achieved clinical response,while 64％ (SE 13％) obtained remission.Separating UC from CD patients,we observed a clinical response in 60％ (SE 16％) and 100％,respectively.Furthermore 60％ (SE 16％) of UC patients and 75％ (SE 25％) of CD patients were in clinical remission after therapy.The median DAI was 7 [interquartile range (IQR):4-8] before treatment and decreased to 2 (IQR:1-3) (P ＜ 0.01) after treatment.Only patients with UC showed a significant reduction of DAI,from a median 6.5 (IQR:4-9) before treatment to 2(IQR:1-3) after treatment (P ＜ 0.01).Conversely,in CD patients,although displaying a clear reduction of DAI from 7 (IQR:5.5-7.5) before therapy to 1.5 (IQR:0.5-2.5) after therapy,differences observed were not significant (P =0.06).Seventy-nine percent (SE 11％)of patients showed improvement of HI of at least 1 point,while only one CD and two UC patients showed HI stability; none showed HI worsening.Median HI decreased from 1 (IQR:1-2),to 0.5 (IQR:0-1) at the endoscopic control in the whole population (P ＜ 0.01),while it changed from 1 (IQR:1-2) to 0.5 (IQR:0-1)in UC patients (P ＜ 0.01) and from 1.5 (IQR:1-2) to 0.5 (IQR:0-1) in CD patients (P =not significant).The two sample tests of proportions showed no significant differences in clinical and histological response or in clinical remission between UC and CD patients.No side effects were reported during treatment or at 4 wk follow-up visit.CONCLUSION:PLC improves endoscopic and histological activity of mild to moderate UC.Further studies are required to evaluate PLC efficacy in colonic CD patients.

Propionyl-L-carnitineUlcerative colitisCrohn's diseaseInflammatory bowel disease therapyPropionyl-L-carnitine hydrochloride

Giuseppe Merra、Giovanni Gasbarrini、Lucrezia Laterza、Marco Pizzoferrato、Andrea Poscia、Franco Scaldaferri、Vincenzo Arena

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Emergency Department, Catholic University of Sacred Heart, 00168 Rome, Italy

Medical Research Foundation and nonprofit organization, 40123 Bologna, Italy

Department of Internal Medicine and Gastroenterology, Catholic University of Sacred Heart, 00168Rome, Italy

Institute of Hygiene, Catholic University of Sacred Heart, 00168 Rome, Italy

Department of Internal Medicine and Gastroenterology, Catholic University of Sacred Heart, 00168 Rome, Italy

Institute of Pathology, Catholic University of Sacred Heart, 00168 Rome, Italy

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2012

10.3748/wjg.v18.i36.5065

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(36)
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