首页|Prognostic value of 18-fluorodeoxyglucose positron emission tomography-computed tomography in resectable colorectal cancer

Prognostic value of 18-fluorodeoxyglucose positron emission tomography-computed tomography in resectable colorectal cancer

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AIM:To assess the prognostic value of preoperative 18 fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) in patients with resectable colorectal cancer.METHODS:One hundred sixty-three patients with resectable colorectal cancer who underwent FDG-PET/CT before surgery were included.Patient data including pathologic stage at presentation,histology,treatment,disease-free survival and the maximum standardized uptake value (SUVmax) of the primary tumor on FDGPET/CT were retrospectively analyzed.Median follow up duration was 756 (range,419-1355).The primary end point was disease-free survival.RESULTS:Twenty-five of 163 patients (15.3％) had recurrences.The median SUVmax values of the recurrence and no-recurrence groups were 8.9 (range,5-24) and 8.2 (range,0-23,P =0.998).Receiver operating characteristic (ROC) curve analysis showed no significant association between SUVmax and recurrence (area under the curve =0.5,P =0.998,95％CI:0.389-0.611).Because a statistically significant value was not found,SUVmax was dichotomized at its median of 8.6.The disease-free survival curve was analyzed using the median SUVmax (8.6) as the cut off.Univariate and multivariate analysis did not provide evidence that disease-free survival rates for the subgroups defined by the median SUVmax were significantly different (P =0.52,P =0.25).CONCLUSION:Our study suggests that the high FDG uptake of primary mass in resectable colorectal cancer doesn't have a significant relationship with tumor recurrence and disease-free survival.

Positron-emission tomographyColorectal neoplasmsDisease-free survivalRecurrencePrognosis

Jang Eun Lee、Sang Woo Kim、Jin Su Kim、Kyu Yong Choi、Won Kyung Kang、Seong Taek Oh、Ie Ryung Yoo

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Department of Internal Medicine, Seoul St.Mary's Hospital,College of Medicine, The Catholic University of South Korea,Seoul 137-701, South Korea

Department of Surgery,College of Medicine, The Catholic University of South Korea,Seoul 137-701, South Korea

Department of Radiology,Seoul St.Mary's Hospital, College of Medicine, The Catholic University of South Korea, Seoul 137-701, South Korea

2012

10.3748/wjg.v18.i36.5072

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(36)
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