首页|Adenosine deaminase activity in tuberculous peritonitis among patients with underlying liver cirrhosis

Adenosine deaminase activity in tuberculous peritonitis among patients with underlying liver cirrhosis

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AIM:To investigate the value of adenosine deaminase (ADA) for early detection of tuberculous peritonitis (TBP) among cirrhotic patients.METHODS:We retrospectively analyzed 22 patients with TBP from July 1990 to June 2010.Twenty-five cirrhotic patients with uninfected ascites were prospectively enrolled as the cirrhosis control group from July 2010 to June 2011.An additional group of 217 patients whose ascites ADA levels were checked in various clinical conditions were reviewed from July 2008 to June 2010 as the validation group.RESULTS:The mean ascites ADA value of cirrhotic patients with TBP (cirrhotic TBP group,n =8) was not significantly different from that of non-cirrhotic patients (non-cirrhotic TBP group,n =14; 58.1 ± 18.8 U/L vs 70.6 ± 29.8 U/L,P =0.29),but the mean ascites ADA value of the cirrhotic TBP group was significantly higher than that of the cirrhosis control group (58.1 ± 18.8 U/L vs 7.0 ± 3.7 U/L,P ＜ 0.001).ADA values were correlated with total protein values (r =0.909,P ＜ 0.001).Using 27 U/L as the cut-off value of ADA,the sensitivity and specificity were 100％ and 93.3％,respectively,for detecting TBP in the validation group.CONCLUSION:Even with lower ADA activity in ascites among cirrhotic patients,ADA values were significantly elevated during TBP,indicating that ADA can still be a valuable diagnostic tool.

ExtrapulmonaryTuberculosisAscitesCirrhosisPeritonitis

Yi-Jun Liao、Chun-Ying Wu、Shou-Wu Lee、Chia-Ling Lee、Sheng-Shun Yang、Chi-Sen Chang、Teng-Yu Lee

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Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan, China

Graduate Institute of Clinical Medical Science, China Medical University, Taichung 407, Taiwan, China

Department of Medicine, Chung Shan Medical University,Taichung 407, Taiwan, China

Medical Record Room, Taichung Veterans General Hospital, Taichung 407, Taiwan, China

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2012

10.3748/wjg.v18.i37.5260

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(37)
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