首页|Different risk factors influence peptic ulcer disease development in a Brazilian population
Different risk factors influence peptic ulcer disease development in a Brazilian population
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AIM:To investigate age,sex,histopathology and Helicobacter pylori (H.pylori) status,as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.METHODS:From all 1466 consecutive dyspeptic patients submitted to upper gastroscopy at Hospital das Clinicas of Marilia,antral biopsy specimens were obtained and subjected to histopathology and H.pylori diagnosis.All patients presenting chronic gastritis (CG)and peptic ulcer (PU) disease localized in the stomach,gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study.Gastric biopsies (n =668) positive for H.pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA) medium (m) region mosaicism by polymerase chain reaction.Logistic regression analysis was performed to verify the association of age,sex,histopathologic alterations,H.pylori diagnosis and vacA m region mosaicism with the incidence of DU,GU and CG in patients.RESULTS:Of 1466 patients submitted to endoscopy,1060 (72.3％) presented CG [male/female =506/554;mean age (year) ± SD =51.2 ± 17.81],88 (6.0％)presented DU [male/female =54/34; mean age (year)± SD =51.4 ± 17.14],and 75 (5.1％) presented GU[male/female =54/21; mean age (year) ± SD =51.3± 17.12] and were included in the comparative analysis.Sex and age showed no detectable effect on CG incidence (overall x2 =2.1,P =0.3423).Sex [Odds ratios (OR) =1.8631,P =0.0058] but not age (OR =0.9929,P =0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall x2 =30.5,P ＜ 0.0001).The histopathological results showed a significant contribution of ageing for both atrophy (OR =1.0297,P ＜ 0.0001) and intestinal metaplasia (OR =1.0520,P ＜ 0.0001).Presence of H.pylori was significantly associated with decreasing age (OR =0.9827,P ＜ 0.0001) and with the incidence of DU (OR =3.6077,P ＜ 0.0001).The prevalence of ml in DU was statistically significant (OR =2.3563,P =0.0018) but not in CG (OR =2.678,P =0.0863) and GU (OR =1.520,P=0.2863).CONCLUSION:In our population,male gender was a risk factor for PU; ageing for GU,atrophy and metapla
Helicobacter pyloriGastric ulcer diseaseDuodenal ulcer diseaseGastric atrophyHelicobacter pylori vacuolating cytotoxin A medium region mosaicism
Rodrigo Buzinaro Suzuki、Rodrigo Faria Cola、Larissa Tranquilino Bardela Cola、Camila Garcia Ferrari、Fred Ellinger、Altino Luiz Therezo、Luis Carlos da Silva
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Department of Genotyping, Hemocenter,Marilia Medical School, Marilia 17519-030, S(a)o Paulo, Brazil
Center for Natural and Human Sciences, Universidade Federal do ABC, Santo André 09210-170, S(a)o Paulo,Brazil
Department of Molecular Biology,Marilia Medical School, Marilia 17519-030, S(a)o Paulo, Brazil
Department of Pathology, Marilia Medical School, Marilia 17519-030, S(a)o Paulo, Brazil
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Funda(ca)o de Amparo a Pesquisa do Estado de S(a)o Paulo (FAPESP)Fellowship CGF
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