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Diagnosis of Zollinger-Ellison syndrome: Increasingly difficult

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In the present paper the increasing difficulty of diagnosis of Zollinger-Ellison syndrome (ZES) due to issues raised in two recent papers is discussed.These issues involve the difficulty and need to withdraw patients suspected of ZES from treatment with Proton Pump Inhibitors (omeprazole,esomeprazole,lansoprazole,rabeprazole,pantoprazole) and the unreliability of many gastrin radioimmunoassays.The clinical context of each of these important issues is reviewed and the conclusions in these articles commented from the perspective of clinical management.

Zollinger-Ellison syndromeGastrinomaHypergastrinemiaSecretin testSerum gastrinGastrinNeuroendocrine tumor

Tetsuhide Ito、Guillaume Cadiot、Robert T Jensen

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Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University,Fukuoka 812-8582, Japan

Hepato-Gastroenterology Service, Centre hospitalier universitaire de Reims, Hospital Robert Debre,F-51092 Reims, France

Digestive Diseases Branch, National Insitutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States

2012

10.3748/wjg.v18.i39.5495

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(39)
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