首页|Inhibition of gastric perception of mild distention by omeprazole in volunteers
Inhibition of gastric perception of mild distention by omeprazole in volunteers
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
维普
To evaluate the effects of omeprazole on gastric mechanosensitivity in humans.METHODS:A double lumen polyvinyl tube with a plastic bag was introduced into the stomach of healthy volunteers under fluorography and connected to a barostat device.Subjects were then positioned so they were sitting comfortably,and the minimal distending pressure (MDP) was determined after a 30-min adaptation period.Isobaric distensions were performed in stepwise increments of 2 mmHg (2 min each) starting from the MDP.Subjects were instructed to score feelings at the end of every step using a graphic rating scale:0,no perception; 1,weak/vague; 2,weak but significant; 3,moderate/vague; 4,moderate but significant; 5,severe discomfort; and 6,unbearable pain.After this first test,subjects received omeprazole (20 mg,after dinner) once daily for 1 wk.A second test was performed on the last day of treatment.RESULTS:No adverse effects were observed.Mean MDP before and after treatment was 6.3 ± 0.3 mmHg and 6.2 ± 0.5 mmHg,respectively.One subject before and 2 after treatment did not reach a score of 6 at the maximum bag volume of 750 mL.After omeprazole,there was a significant increase in the distension pressure required to reach scores of 1 (P =0.019) and 2(P =0.017) as compared to baseline.There were no changes in pressure required to reach the other scores after treatment.Two subjects before and one after omeprazole rated their abdominal feeling ＜ 1 at MDP,and mean (± SE) abdominal discomfort scores at MDP were 0.13 ±± 0.09 and 0.04 ±± 0.04,respectively.Mean scores induced by each MDP + 2,4,6,8,10,12,14,16,18 and 20 (mmHg) were 1.1 ± 0.3,2.0 ± 0.4,2.9± 0.5,3.3 ± 0.4,4.6 ± 0.3,5.2 ± 0.3,5.5 ± 0.2,5.5± 0.3,5.7 ± 0.3,and 5.4,respectively.After omeprazole,abdominal feeling scores for the same incremental pressures over MDP were 0.3 ± 0.1,0.8 ± 0.1,2.0±-0.4,2.8-0.4,3.8 ±± 0.4,4.6 ±± 0.4,4.9 ± 0.3,5.4± 0.4,5.2 ±± 0.6,and 5.0 ±± 1.0,respectively.A significant decrease in feeling score was observed at intrabag pressures of MDP + 2 mmHg (P =0.028) and +4 mmHg (P =0.013),respectively,after omeprazole.No significant score changes were observed at pressures ≥ MDP + 6 mmHg.CONCLUSION:Although the precise mechanisms are undetermined,the present study demonstrated that omeprazole decreases mechanosensitivity to mild gastric distension.
NETL
NSTL
万方数据
维普
