首页|Sarcoidosis and chronic hepatitis C: A case report

Sarcoidosis and chronic hepatitis C: A case report

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Several case reports deal with the relationship between hepatitis C virus (HCV) infection and pulmonary or hepatic sarcoidosis.Most publications describe interferon α-induced sarcoidosis.However,HCV infection per se is also suggested to cause sarcoidosis.The present case report describes a case of biopsy-verified lung and liver sarcoidosis and HCV infection,and the outcome of antiviral therapy.In March 2009,a 25-year-old man presented with moderately elevated liver enzymes without any clinical symptoms.The patient was positive for HCV antibodies and HCV RNA of genotype 1b.Four months later the patient became dyspnoic and pulmonary sarcoidosis was diagnosed by lung biopsy and radiography.A short course of corticosteroid treatment relieved symptoms.Three months later,liver biopsy showed noncaseating granulomas consisting of epithelioid histiocytes and giant cells with a small amount of peripheral lymphocyte infiltration,without any signs of fibrosis.Chronic HCV infection with coexistence of pulmonary and hepatic sarcoidosis was diagnosed.Antiviral therapy with peginterferon α and ribavirin at standard doses was started,which lasted 48 wk,and sustained viral response was achieved.A second liver biopsy showed disappearance of granulomas and chest radiography revealed normalization of mediastinal and perihilar glands.The hypothesis that HCV infection per se may have triggered systemic sarcoidosis was proposed.Successful treatment of HCV infection led to continuous remission of pulmonary and hepatic sarcoidosis.Further studies are required to understand the relationship between systemic sarcoidosis and HCV infection.

Pulmonary and hepatic sarcoidosisHepatitis C virus infectionSustained viral responsePeginterferon αRibavirin

Vadim Brjalin、Riina Salupere、Valentina Tefanova、Kaiu Prikk、Natalia Lapidus、Enn J(o)este

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Department of Internal Medicine, West-Tallinn Central Hospital, 10617 Tallinn, Estonia

Department of Internal Medicine, University of Tartu, 51014 Tartu, Estonia

Department of Virology, National Institute for Health Development, 11619 Tallinn, Estonia

Institute of Clinical Medicine, Tallinn University of Technology, 19086 Tallinn, Estonia

Department of Pathology, West-Tallinn Central Hospital, 10617 Tallinn, Estonia

Department of Pathology, North Estonia Medical Centre, 13419 Tallinn, Estonia

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A grant from the Estonian Science FoundationUniversity of Tartu

7650SF0180081s07

2012

10.3748/wjg.v18.i40.5816

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(40)
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