首页|High-fibre diet and Lactobacillus paracasei B21060 in symptomatic uncomplicated diverticular disease
High-fibre diet and Lactobacillus paracasei B21060 in symptomatic uncomplicated diverticular disease
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NETL
NSTL
万方数据
维普
AIM:TO investigate in symptomatic uncomplicated diverticular disease the efficacy of symbiotics associated with a high-fibre diet on abdominal symptoms.METHODS:This study was a multicentre,6-mo randomized,controlled,parallel-group intervention with a preceding 4-wk washout period.Consecutive outpatients with symptomatic uncomplicated diverticular disease,aged 40-80 years,evaluated in 4 Gastroenterology Units,were enrolled.Symptomatic uncomplicated diverticular disease patients were randomized to two treatment arms A or B.Treatment A (n =24 patients)received 1 symbiotic sachet Flortec(c) (Lactobacillus paracasei B21060) once daily plus high-fibre diet for 6 mo.Treatment B (n =21 patients) received high-fibre diet alone for 6 mo.The primary endpoint was regression of abdominal symptoms and change of symptom severity after 3 and 6 mo of treatment.RESULTS:In group A,the proportion of patients with abdominal pain ＜ 24 h decreased from 100％ at baseline to 35％ and 25％ after 3 and 6 mo,respectively (P＜ 0.001).In group B the proportion of patients with this symptom decreased from 90.5％ at baseline to 61.9％ and 38.1％ after 3 and 6 mo,respectively (P =0.001).Symptom improvement became statistically significant at 3 and 6 mo in group A and B,respectively.The proportion of patients with abdominal pain ＞24h decreased from 60％ to 20％ then 5％ after 3 and 6 mo,respectively in group A (P ＜ 0.001) and from 33.3％ to 9.5％ at both 3 and 6 mo in group B (P =0.03).In group A the proportion of patients with abdominal bloating significantly decreased from 95％ to 60％ after 3 mo,and remained stable (65％) at 6-mo follow-up (P =0.005) while in group B,no significant changes in abdominal bloating was observed (P =0.11).After 6 mo of treatment,the mean visual analogic scale (VAS) values of both short-lasting abdominal pain (VAS,mean ± SD,group A:4.6 ± 2.1 vs 2.2 ± 0.8,P =0.02;group B:4.6±2.9 vs 2.0 ± 1.9,P =0.03) and abdominal bloating (VAS,mean ± SD,group A:5.3 ± 2.2 vs 3.0± 1.7,P =0.005; group B:5.3 ± 3.2 vs 2.3 ± 1.9,P =0.006) decreased in both groups,whilst the VAS values of prolonged abdominal pain decreased in the Flortec(c)group,but remained unchanged in the high-fibre dietgroup (VAS,mean ± SD,group A:6.5 ± 1.5 vs 4.5 ±2.1,P =0.052; group B:4.5 ± 3.8 vs 5.5 ± 3.5).CONCLUSION:A high-fibre diet is effective in relieving abdominal symptoms in symptomatic uncomplicated diverticular disease.This treatment may be implemented by combining the high-fibre diet with Flortec(c).
NETL
NSTL
万方数据
维普
