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MicroRNAs in biliary diseases

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Cholangiopathies are a group of diseases primarily or secondarily affecting bile duct cells,and result in cholangiocyte proliferation,regression,and/or transformation.Their etiopathogenesis may be associated with a broad variety of causes of different nature,which includes genetic,neoplastic,immune-associated,infectious,vascular,and drug-induced alterations,or being idiopathic.miRNAs,small non-coding endogenous RNAs that post-transcriptionally regulate gene expression,have been associated with pathophysiological processes in different organs and cell types,and are postulated as potential targets for diagnosis and therapy.In the current manuscript,knowledge regarding the role of miRNAs in the development and/or progression of cholangiopathies has been reviewed and the most relevant findings in this promising field of hepatology have been highlighted.

miRNAsCholangiopathiesCholangiocarcinomaPolycystic liver diseasesPrimary biliary cirrhosis

Patricia Munoz-Garrido、Maite García-Fernández de Barrena、Elizabeth Hijona、Miguel Carracedo、José J G Marín、Luis Bujanda、Jesús M Banales

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Division of Hepatology and Gastroenterology, Biodonostia Research Institute, Donostia Universitary Hospital, 20014 San Sebastián, Spain

Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic,Rochester, MN 55905, United States

Department of Liver and Gastrointestinal Diseases,National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehd, funded by the Spanish Carlos Ⅲ Institute), 08036 Barcelona, Spain

Department of Physiology and Pharmacology,Experimental Hepatology and Drug Targeting(HEVEFARM),Biomedical Research Institute of Salamanca(IBSAL), University of Salamanca, 37008 Salamanca, Spain

Ikerbasque, Basque Foundation for Science,48011 Bilbao, Spain

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2012

10.3748/wjg.v18.i43.6189

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(43)
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