首页|Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma

Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma

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AIM:To compare the clinicopathological characteristics of human epidermal growth factor receptor 2 (HER2)-positive and HER2-negative Barrett's adenocarcinoma in Japan.METHODS:We performed immunohistochemical analysis of HER2 in 30 samples taken from patients with Barrett's adenocarcinoma and dual color in situ hybridization in cases showing 2+ reactions.We compared the clinicopathological characteristics of HER2-positive and HER2-negative patients.RESULTS:HER2 positivity was identified in 8 (27％) carcinoma samples.We found that HER2 expression was associated with p53 overexpression (100％ vs 52.6％ in pT1 tumor; 100％ vs 54.5％ in all stage tumor,P ＜ 0.05) and protruding lesions at the early disease stage.There was no association between the mucin phenotype of the carcinomas and prognosis.HER2 expression and low clinical stage were unexpectedly different between Barrett's adenocarcinoma patients and gastric cancer patients,but the macroscopic features may be associated with earlier diagnosis in these patients.CONCLUSION:Our results suggest that HER2-positive Barrett's adenocarcinomas are associated with p53 overexpression and lesion protrusion at the early disease stage.

Barrett's adenocarcinomaHuman epidermal growth factor receptor 2p53Mucin phenotype

Takehiro Tanaka、Atsushi Fujimura、Koichi Ichimura、Hiroyuki Yanai、Yasuharu Sato、Katsuyohi Takata、Hiroyuki Okada

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Department of Pathology, Okayama University Hospital, Okayama 700-8558, Japan

Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan

Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan

Department of Endoscopy,Okayama University Hospital, Okayama 700-8558, Japan

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2012

10.3748/wjg.v18.i43.6263

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(43)
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