首页|Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection

Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection

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AIM:To investigate whether the addition of probiotics can improve the eradication effect of triple therapy for Helicobacter pylori (H.pylori) infection.METHODS:This open randomized trial recruited 234 H.pylori positive gastritis patients from seven local centers.The patients were randomized to one-week standard triple therapy (omeprazole 20 mg bid,clarithromycin 500 mg bid,and amoxicillin 1000 mg bid; OCA group,n =79); two weeks of pre-treatment with probiotics,containing 3 × 107 Lactobacillus acidophilus per day,prior to one week of triple therapy (POCA group,n =78); or one week of triple therapy followed by two weeks of the same probiotics (OCAP group,n =77).Successful eradication was defined as a negative C13 or C14 urease breath test four weeks after triple therapy.Patients were asked to report associated symptoms at baseline and during follow-up,and side effects related to therapy were recorded.Data were analyzed by both intention-to-treat (ITT) and per-protocol (PP) methods.RESULTS:PP analysis involved 228 patients,78 in the OCA,76 in the POCA and 74 in the OCAP group.Successful eradication was observed in 171 patients; by PP analysis,the eradication rates were significantly higher (P =0.007 each) in the POCA (62/76; 81.6％,95％CI 72.8％-90.4％) and OCAP (61/74; 82.4％,95％ CI 73.6％-91.2％) groups than in the OCA group (48/78;61.5％,95％ CI 50.6％-72.4％).ITT analysis also showed that eradication rates were significantly higher in the POCA (62/78; 79.5％,95％ CI 70.4％-88.6％)and OCAP (61/77; 79.2％,95％ CI 70％-88.4％)groups than in the OCA group (48/79; 60.8％,95％ CI 49.9％-71.7％),(P =0.014 and P =0.015).The symptom relieving rates in the POCA,OCAP and OCA groups were 85.5％,89.2％ and 87.2％,respectively.Only one of the 228 patients experienced an adverse reaction.CONCLUSION:Administration of probiotics before or after standard triple therapy may improve H.pylori eradication rates.

Helicobacter pyloriProbioticEradication

Yi-Qi Du、Tun Su、Jian-Gao Fan、Yu-Xia Lu、Ping Zheng、Xing-Hua Li、Chuan-Yong Guo

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Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai 200240, China

Department of Gastroenterology, Tongji Hospital,Tong Ji University, Shanghai 200092, China

Department of Gastroenterology, Shanghai First People's Hospital, Shanghai 201620, China

Department of Gastroenterology, Shanghai Eighth People's Hospital, Shanghai 210035, China

Department of Gastroenterology, Shanghai Tenth People's Hospital, Shanghai 200072, China

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China National Science and Technology Major Project

2012ZX09303-011-002

2012

10.3748/wjg.v18.i43.6302

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(43)
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