首页|Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis

Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis

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Obstructive jaundice occurs in patients suffering from cholelithiasis and from neoplasms affecting the pancreas and the common bile duct.The absorption,distribution and elimination of drugs are impaired during this pathology.Prolonged cholestasis may alter both liver and kidney function.Lactam antibiotics,diuretics,non-steroidal anti-inflammatory drugs,several antiviral drugs as well as endogenous compounds are classified as organic anions.The hepatic and renal organic anion transport pathways play a key role in the pharmacokinetics of these compounds.It has been demonstrated that acute extrahepatic cholestasis is associated with increased renal elimination of organic anions.The present work describes the molecular mechanisms involved in the regulation of the expression and function of the renal and hepatic organic anion transporters in extrahepatic cholestasis,such as multidrug resistanceassociated protein 2,organic anion transporting polypeptide 1,organic anion transporter 3,bilitranslocase,bromosulfophthalein/bilirubin binding protein,organic anion transporter 1 and sodium dependent bile salt transporter.The modulation in the expression of renal organic anion transporters constitutes a compensatory mechanism to overcome the hepatic dysfunction in the elimination of organic anions.

Organic anionsLiverKidneyMultidrug resistance-associated protein 2Organic anion transporting polypeptide 1Organic anion transporter 3BilitranslocaseBromosulfophthalein/bilirubin binding proteinOrganic anion transporter 1Sodium dependent b

Anabel Brandoni、María Herminia Hazelhoff、Romina Paula Bulacio、Adriana Mónica Torres

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Pharmacology Unit, Department of Physiological Sciences, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, the National Scientific and Technical Research Council, 2000 Rosario,Argentine

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PICT 200700966PICT 20102127PIP 2009-20111665PIP 2012-2015000142008-2011/2012-2015

2012

10.3748/wjg.v18.i44.6387

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(44)
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