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Malakoplakia of the esophagus caused by human papillomavirus infection

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Malakoplakia is a rare granulomatous disease probably caused by infection and characterized histologically by Michaelis-Gutmann bodies.We report a more rarely seen case esophageal malakoplakia in a 54-year-old woman.She presented with coughing while eating and drinking.Gastroscopy showed yellow nodules in the esophagus,and endoscopic ultrasonography showed a space-occupying lesion in the substratum of the esophageal mucosa.All findings highly resembled esophageal cancer.Histopathological examination finally indentified this space-occupying lesion as malakoplakia and not cancer.Immunohistochemistry showed that she had human papillomavirus (HPV) infection in the esophagus,which indicates that infection was responsible for the malakoplakia.This is believed to be the first case of malakoplakia in the esophagus,and more importantly,we established that HPV infection was the initiator of esophageal malakoplakia.

MalakoplakiaEsophagusMichaelis-Gutmann bodiesHuman papillomavirus infection

Ya-Li Yang、Yu-Cheng Xie、Xiao-Ling Li、Jing Guo、Tao Sun、Jing Tang

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Department of Pathology, Yunnan Province Second People's Hospital, Kunming 650021, Yunnan Province, China

Department of Pathology, Changzhou Traditional Chinese Medical Hospital, Changzhou 231000, Jiangsu Province, China

2012

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子:1.001
ISSN:1007-9327
年,卷(期):2012.18(45)
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