Esophagus and regenerative medicine

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外文摘要：In addition to squamous cell carcinoma,the incidence of Barrett's esophagus with high-grade dysplasia and esophageal adenocarcinoma is rapidly increasing worldwide.Unfortunately,the current standard of care for esophageal pathology involves resection of the affected tissue,sometimes involving radical esophagectomy.Without exception,these procedures are associated with a high morbidity,compromised quality of life,and unacceptable mortality rates.Regenerative medicine approaches to functional tissue replacement include the use of biological and synthetic scaffolds to promote tissue remodeling and growth.In the case of esophageal repair,extracellular matrix (ECM) scaffolds have proven to be effective for the reconstruction of small patch defects,anastomosis reinforcement,and the prevention of stricture formation after endomucosal resection (EMR).More so,esophageal cancer patients treated with ECM scaffolds have shown complete restoration of a normal,functional,and disease-free epithelium after EMR.These studies provide evidence that a regenerative medicine approach may enable aggressive resection of neoplastic tissue without the need for radical esophagectomy and its associated complications.

外文关键词：

Esophageal repairBiomaterial mediated esophageal repairExtracellular matrixExtracellular matrix scaffold

作者：

Ricardo Londono、Blair A Jobe、Toshitaka Hoppo、Stephen F Badylak

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作者单位：

McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, United States

School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, United States

Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA 15232,United States

McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, United States Ricardo Londono, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, United States

Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, United States

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, United States

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基金：

National Institute of Biomedical Imaging and Bioengineering,in part

项目编号：

T32EBO01026-08

出版年：

2012

DOI：

10.3748/wjg.v18.i47.6894

世界胃肠病学杂志(英文版)