首页|How regenerative medicine and tissue engineering may complement the available armamentarium in gastroenterology?

How regenerative medicine and tissue engineering may complement the available armamentarium in gastroenterology?

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The increasing shortage of donors and the adverse effects of immunosuppression have restricted the impact of solid organ transplantation.Despite the initial promising developments in xenotransplantation,roadblocks still need to be overcome and this form of organ support remains a long way from clinical practice.While hepatocyte transplantation may be effectively correct metabolic defects,it is far less effective in restoring liver function than liver transplantation.Tissue engineering,using extracellular matrix scaffolds with an intact but decellularized vascular network that is repopulated with autologous or allogeneic stem cells and/or adult cells,holds great promise for the treatment of failure of organs within gastrointestinal tract,such as endstage liver disease,pancreatic insufficiency,bowel failure and type 1 diabetes.Particularly in the liver field,where there is a significant mortality of patients awaiting transplant,human bioengineering may offer a source of readily available organs for transplantation.The use of autologous cells will mitigate the need for long term immunosuppression thus removing a major hurdle in transplantation.

Regenerative medicineTissue engineeringOrgan transplantationCellular transplantationXenotransplantation

Marco Carbone、Jan Lerut、James Neuberger

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Addenbrookes Hospital, Cambridge CB2 0QQ, United Kingdom

Starzl Abdominal Transplant Unit, University Hospitals St.Luc, Université Catholique de Louvain, B-1200 Bruxelles, Belgium

Organ Donation and Transplantation, NHS Blood and Transplant, Fox Den Road, Bristol BS34 8RR,United Kingdom

2012

10.3748/wjg.v18.i47.6908

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(47)
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