首页|-449 C＞G polymorphism of NFKB1 gene, coding nuclear factor-kappa-B, is associated with the susceptibility to ulcerative colitis
-449 C＞G polymorphism of NFKB1 gene, coding nuclear factor-kappa-B, is associated with the susceptibility to ulcerative colitis
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AIM:To clarify the association between a polymorphism-449 C＞G (rs72696119) in 5'-UTR of NFKB1 with ulcerative colitis (UC).METHODS:The studied population comprised 639subjects,including patients with UC (UC cases,n =174) and subjects without UC (controls,n =465).We employed polymerase chain reaction-single strand conformation polymorphism to detect the gene polymorphism.RESULTS:The rs72696119 G allele frequencies in controls and UC cases were 33.4％ and 38.5％,respectively (P =0.10).Genotype frequency of the GG homozygote in UC cases was significantly higher than that in controls (P =0.017),and the GG homozygote was significantly associated with susceptibility to UC [odds ratio (OR),1.88; 95％CI,1.13-3.14].In male subjects,the GG homozygote was associated with an increased risk for UC (OR,3.10; 95％CI,1.47-6.54; P =0.0053),whereas this association was not found in female subjects.In addition,the GG homozygote was significantly associated with the risk of non-continuous disease (OR,2.06; 95％CI,1.12-3.79; P =0.029),not having total colitis (OR,2.40; 95％CI,1.09-3.80,P =0.040),disease which developed before 20 years of age (OR,2.80; 95％CI,1.07-7.32,P =0.041),no hospitalization (OR,2.28; 95％CI,1.29-4.05; P =0.0090) and with a maximum of 8 or less on the UCDAI score (OR,2.45;95％CI,1.23-4.93; P =0.022).CONCLUSION:Our results provide evidence that NFKB1 polymorphism rs72696119 was significantly associated with the development of UC.This polymorphism influences the susceptibility to and pathophysiological features of UC.
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