首页|Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment

Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment

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  • NSTL
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AIM:To investigate the patterns and decisive prognostic factors for local recurrence of rectal cancer treated with a multidisciplinary team (MDT) modality.METHODS:Ninety patients with local recurrence were studied,out of 1079 consecutive rectal cancer patients who underwent curative surgery from 1999 to 2007.For each patient,the recurrence pattern was assessed by specialist radiologists from the MDT using imaging,and the treatment strategy was decided after discussion by the MDT.The associations between clinicopathological factors and long-term outcomes were evaluated using both univariate and multivariate analysis.RESULTS:The recurrence pattern was classified as follows:Twenty-seven (30％) recurrent tumors were evaluated as axial type,21 (23.3％) were anterior type,8 (8.9％) were posterior type,and 13 (25.6％) were lateral type.Forty-one patients had tumors that were evaluated as resectable by the MDT and ultimately received surgery,and R0 resection was achieved in 36 (87.8％) of these patients.The recurrence pattern was closely associated with resectability and R0 resection rate (P ＜ 0.001).The recurrence pattern,interval to recurrence,and RO resection were significantly associated with 5-year survival rate in univariate analysis.Multivariate analysis showed that the R0 resection was the unique independent factor affecting long-term survival.CONCLUSION:The MDT modality improves patient selection for surgery by enabling accurate classification of the recurrence pattern; RO resection is the most significant factor affecting long-term survival.

Rectal cancerLocal recurrencePrognosisSurvivalSurgery

Jun Zhao、Chang-Zheng Du、Ying-Shi Sun、Jin Gu

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Department of Colorectal Surgery, Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Peking University Cancer Hospital, Beijing Cancer Hospital and Institute, Beijing 100142, China

Department of Radiology, Peking University Cancer Hospital, Beijing 100142, China

2012

10.3748/wjg.v18.i47.7015

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(47)
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