首页|Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities
Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities
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AIM:To investigate the associations between interleukin (IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet,Hui and Han ethnicities.METHODS:Genomic DNA was extracted from peripheral blood of 210,205,and 202 healthy volunteers and from 155,158,and 197 gastric cancer patients from the Tibet,Hui,and Han populations,respectively.Polymorphisms in IL-1B and IL-1RN were analyzed by denaturing high-performance liquid chromatography.RESULTS:Carriers of the IL-1B-31 CC genotype had an increased risk of intestinal type gastric cancer [odds ratio (OR) =2.17,P =0.037] in the Tibet ethnicity.Carriers of the IL-1B 2/L genotype had an increased risk of both intestinal and diffuse types of gastric cancer (OR =2.08,2.31,P =0.007,0.016,respectively)in the Hui ethnicity.In the Han population,carriers of the IL-1B-31 CC,IL-1B-511CT,TT genotypes had increased risk of intestinal type gastric cancer (OR =2.51,2.74,5.66,P =0.005,0.002,0.000,respectively).CONCLUSION:IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet,Hui,and Han ethnicities in the Qinghai area of China.
Gastric cancerInterleukin-1BInterleukin1RNPolymorphismRisk of gastric cancer
Jiu-Da Zhao、Pai-Li Geng、Zhan-Quan Li、Sen Cui、Jun-Hui Zhao、Li-Juan Wang、Jin-Zhang Li
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Internal Medicine-Oncology, Affiliated Hospital of Qinghai University,Xining 810000, Qinghai Province, China
High Altitude Medical Research Center, Qinghai University, Xining 810000,Qinghai Province, China
国家自然科学基金Youth Scientific Research Foundation of Qinghai University
NETL
NSTL
万方数据
维普
