首页|Carcinoma of the gastroesophageal junction in Chinese patients

Carcinoma of the gastroesophageal junction in Chinese patients

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  • NSTL
  • 万方数据
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Carcinoma of the gastroesophageal junction (GEJ) is defined as carcinoma that crosses the GEJ line,irrespective of where the tumor epicenter is located.This group of cancer is rare but controversial.Based on study results from the majority of epidemiologic and clinicopathologic investigations carried out in Western countries,this cancer is believed to arise from Barrett's esophagus (BE) and includes both distal esophageal and proximal gastric carcinomas because of similar characteristics in epidemiology,clinicopathology,and molecular pathobiology in relation to BE.As such,the most recent American Joint Committee on Cancer staging manual requires staging all GEJ carcinomas with the rule for esophageal adenocarcinoma (EA).This mandate has been challenged recently by the data from several studies carried out mainly in Chinese patients.The emerging evidence derived from those studies suggests:(1) both BE and EA are uncommon in the Chinese population; (2) almost all GEJ cancers in Chinese arise in the proximal stomach and show the features of proximal gastric cancer,not those of EA; (3) application of the new cancer staging rule to GFJ cancer of Chinese patients cannot stratify patients' prognosis effectively; and (4) prognostic factors of GEJ cancer in Chinese are similar,but not identical,to those of EA.In conclusion,the recent evidence suggests that GFJ cancer in Chinese shows distinct clinicopathologic characteristics that are different from EA.Further investigations in molecular pathology may help illustrate the underlying pathogenesis mechanisms of this cancer in Chinese patients and better manage patients with this fatal disease.

EsophagusStomachCancerGastroesophageal junctionStagingBarrett's esophagus

Qin Huang

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Department of Pathology, Nanjing Drum Tower Hospital, Nanjing 020008, Jiangsu Province, China

Department of Pathology and Laboratory Medicine, Veterans Affairs Boston Healthcare System and Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, United States

Science and Technology Development Project of the Nanjing City in ChinaScience and Technology Development Project of the Nanjing City in ChinaNanjing Drum Tower Hospital in Nanjing,China

ZKX05013ZKX07011

2012

10.3748/wjg.v18.i48.7134

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(48)
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