首页|Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile duct-ligated rats and human hepatic stellate cells
Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile duct-ligated rats and human hepatic stellate cells
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AIM:To investigate the anti-hepatofibrotic effects of Gardenia jasminoides in liver fibrosis.METHODS:Male Sprague-Dawley rats underwent common bile duct ligation (BDL) for 14 d and were treated with Gardenia jasminoides by gavage.The effects of Gardenia jasminoides on liver fibrosis and the detailed molecular mechanisms were also assessed in human hepatic stellate cells (LX-2) in vitro.RESULTS:Treatment with Gardenia jasminoides decreased serum alanine aminotransferase (BDL vs BDL +100 mg/kg Gardenia jasminoides,146.6 ± 15 U/L vs 77± 6.5 U/L,P =0.0007) and aspartate aminotransferase (BDL vs BDL + 100 mg/kg Gardenia jasminoides,188 ± 35.2 U/L vs 128 ± 19 U/L,P =0.005) as well as hydroxyproline (BDL vs BDL + 100 mg/kg Gardenia jasminoides,438 ± 40.2 μg/g vs 228 ± 10.3 μg/g liver tissue,P =0.004) after BDL.Furthermore,Gardenia jasminoides significantly reduced liver mRNA and/or protein expression of transforming growth factor β1(TGF-β1),collagen type Ⅰ (Col Ⅰ) and α-smooth muscle actin (α-SMA).Gardenia jasminoides significantly suppressed the upregulation of TGF-β1,Col Ⅰ and α-SMA in LX-2 exposed to recombinant TGF-β1.Moreover,Gardenia jasminoides inhibited TGF-β1-induced Smad2 phosphorylation in LX-2 cells.CONCLUSION:Gardeniajasminoides exerts antifibrotic effects in the liver fibrosis and may represent a novel antifibrotic agent.
Gardenia jasminoidesLiver fibrosisCollagen type ⅠTransforming growth factor-β1/Smad2 pathwayα-smooth muscle actin
Ying-Hua Chen、Tian Lan、Jing Li、Chun-Hui Qiu、Teng Wu、Hong-Ju Gou、Min-Qiang Lu
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The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Institute of Vascular Biology, Guangdong Pharmaceutical University, Guangzhou 510006,Guangdong Province, China
Guangzhou PTDS Biotechnology Science and Technology Co.Ltd., Guangzhou 510540, Guangdong Province, China
Department of Hepatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
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Natural Science Foundation of ChinaNatural Science Foundation of ChinaPhD Start-up Fund of Natural Science Foundation of Guangdong Province,ChinaNew Star of Science and Technology Foundation of Zhu Jiang in Guangzhou City
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