首页|Age-related symptom and life quality changes in women with irritable bowel syndrome
Age-related symptom and life quality changes in women with irritable bowel syndrome
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AIM:To explore age-related changes in symptoms and quality of life (QoL) of women with irritable bowel syndrome (IBS).METHODS:Two-hundred and fifty-four female adult outpatients with IBS attending the Department of Gastroenterology at the First Affiliated Hospital of Nanjing Medical University between January,2008 and October,2008 were approached.Patients with a history of abdominal surgery,mental illness or those who had recently taken psychotropic drugs were excluded.A physician obtained demographic and abdominal symptom data.All patients were asked to complete the Zung Self-Rated Anxiety and Depression Scale (SDS/SAS) and the IBS-specific QoL questionnaire.The patients were divided into six groups according to age,in 10-year increments:18-27 years,28-37 years,38-47 years,48-57 years,58-67 years and 68-75 years (maximum 75 years).Age-related differences of abdominal pain or discomfort were analyzed using ranksum tests.Differences in SDS/SAS and IBS-QoL scores between age groups were analyzed using one-way analysis of variance.Pearson's correlations evaluated potential associations between IBS symptoms,psychological factors and QoL in each age group.RESULTS:There were no differences in the distribution of IBS subtypes between age groups (x2 =20.516,P =0.153).Differences in the severity of abdominal pain/discomfort with age were statistically significant (x2 =25.638,P ＜ 0.001); patients aged 48-57 years,58-67 years or 68-75 years had milder abdominal pain/discomfort than those in the younger age groups.The severity of anxiety or depressive symptoms did not differ between age groups (SDS,x2 =390.845,P =0.110;SAS,x2 =360.071,P =0.220).Differences of IBSQoL scores were statistically significant between age groups (x2 =1098.458,P =0.011).The scores of patients in the 48-57-year group were lower than those in the 18-27-year and 28-37-year groups (48-57-year group vs 18-27-year group,74.88 ± 8.76 vs 79.76± 8.63,P =0.021; 48-57-year group vs 28-37-year group,74.88 ± 8.76 vs 79.04 ± 8.32,P =0.014).The scores in the 68-75-year group were lower than those in the 18-27-year,28-37-year and 38-47-year groups (68-75-year group w 18-27-year group,71.98± 9.83 w 79.76 ± 8.63,P =0.003; 68-75-year group vs 28-37-year group,71.98 ± 9.83 w 79.04 ± 8.32,P =0.002; 68-75-year group vs 38-47-year group,71.98 ± 9.83 vs 76.44 ± 8.15,P =0.039).Anxiety and depression were negatively correlated with QoL in all age groups (SDS and QoL:18-27-year group,r =-0.562,P =0.005; 28-37-year group,r =-0.540,P ＜ 0.001;38-47-year group,r =-0.775,P ＜ 0.001; 48-57-year group,r =-0.445,P =0.001; 58-67-year group,r =-0.692,P ＜ 0.001; 68-75-year group,r =-0.732,P ＜0.001.SAS and QoL:18-27-year group,r =-0.600,P =0.002; 28-37-year group,r =-0.511,P ＜ 0.001;38-47-year group,r =-0.675,P ＜ 0.001; 48-57-year group,r =-0.558,58-67-year group,P =0.001; r =-0.588,P ＜ 0.001; 68-75-year group,r =-0.811,P＜ 0.001).A negative correlation between abdominal pain severity and QoL was found in patients aged more than 58 years (58-67-year group,r =-0.366,P =0.017; 68-75-year group,r =-0.448,P =0.048),but not in younger patients (18-27-year group,r =0.080,P =0.716; 28-37-year group,r =-0.063,P =0.679;38-47-year group,r =-0.029,P =0.812; 48-57-year group,r =-0.022,P =0.876).CONCLUSION:Factors affecting QoL should always be treated in IBS,especially emotional problems in young adults.Even mild abdominal pain should be controlled in elderly patients.
Irritable bowel syndromeFemaleAgeSymptomQuality of life
Yu-Rong Tang、Wei-Wei Yang、Mei-Lan Liang、Xin-Yu Xu、Mei-Feng Wang、Lin Lin
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Department of Gastroenterology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029, Jiangsu Province, China
Department of Gastroenterology, Nanjing Jiangbei People's Hospital, Medical School, Southeast University, Nanjing 210048, Jiangsu Province, China
Open Project Program of the Jiangsu Key Laboratory of Molecular and Functional ImagingMedical Science and Technology Development Foundation of Nanjing Department of Health
NETL
NSTL
万方数据
维普
