首页|Comparison between air and carbon dioxide insufflation in the endoscopic submucosal excavation of gastrointestinal stromal tumors

Comparison between air and carbon dioxide insufflation in the endoscopic submucosal excavation of gastrointestinal stromal tumors

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AIM:To evaluate the safety and efficacy of CO2 insufflation compared with air insufflation in the endoscopic submucosal excavation (ESE) of gastrointestinal stromal tumors.METHODS:Sixty patients were randomized to undergo endoscopic submucosal excavation,with the CO2 group (n =30) and the air group (n =30) undergoing CO2 insufflation and air insufflation in the ESE,respectively.The end-tidal CO2 level (pETCO2) was observed at 4 time points:at the beginning of ESE,at total removal of the tumors,at completed wound management,and 10 min after ESE.Additionally,the patients'experience of pain at 1,3,6 and 24 h after the examination was registered using a visual analog scale (VAS).RESULTS:Both the CO2 group and air group were similar in mean age,sex,body mass index (all P ＞ 0.05).There were no significant differences in PetCO2 values before and after the procedure (P ＞ 0.05).However,the pain scores after the ESE at different time points in the CO2 group decreased significantly compared with the air group (1 h:21.2 ± 3.4 vs 61.5 ± 1.7; 3 h:8.5± 0.7 vs 42.9 ± 1.3; 6 h:4.4 ± 1.6 vs 27.6 ± 1.2; 24h:2.3 ± 0.4 vs 21.4 ± 0.7,P ＜ 0.05).Meanwhile,the percentage of VAS scores of 0 in the CO2 group after 1,3,6 and 24 h was significantly higher than that in the air group (60.7 ± 1.4 vs 18.9 ± 1.5,81.5 ± 2.3 vs 20.6 ± 1.2,89.2 ± 0.7 vs 36.8 ± 0.9,91.3 ± 0.8 vs 63.8 ± 1.3,respectively,P ＜ 0.05).Moreover,the condition of the CO2 group was better than that of the air group with respect to anal exsufflation.CONCLUSION:Insufflation of CO2 in the ESE of gastrointestinal stromal tumors will not cause CO2 retention and it may significantly reduce the level of pain,thus it is safe and effective.

Carbon dioxide insufflationEndoscopic submucosal excavationGastrointestinal tractStromal tumorTreatment

Wei-Bin Shi、Zi-Hao Wang、Chun-Ying Qu、Yi Zhang、Han Jiang、Min Zhou、Ying Chen

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Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China

Digestive Endoscopic Diagnosis and Treatment Center,Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China

Shanghai Key Laboratory of Pediatric Digestion and Nutrition, Shanghai 200092, China

Supported by Grants from Project of Science and Technology Commission of Shanghai MunicipalityNano-specific Project of Science and Technology Commission of Shanghai MunicipalityShanghai Key Laboratory of Pediatric Digestion and Nutrition

1044190170211nm050370011DZ2260500

2012

10.3748/wjg.v18.i48.7296

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(48)
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