首页|Serum pepsinogen Ⅱ is a better diagnostic marker in gastric cancer

Serum pepsinogen Ⅱ is a better diagnostic marker in gastric cancer

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AIM:To investigate screening makers for gastric cancer,we assessed the association between gastric cancer and serum pepsinogens (PGs).METHODS:The subjects comprised 450 patients with gastric cancer,111 individuals with gastric atrophy,and 961 healthy controls.Serum anti-Helicobacter pylori (H.pylori) immunoglobulin G (IgG),PG Ⅰ and PG Ⅱ were detected by enzyme-linked immunosorbent assay.Gastric atrophy and gastric cancer were diagnosed by endoscopy and histopathological examinations.Odds ratios and 95％CIs were calculated using multivariate logistic regression.RESULTS:Rates of H.pylori infection remained high in Northeastern China.Rates of H.pylori IgG positivity were greater in the gastric cancer and gastric atrophy groups compared to the control group (69.1％ and 75.7％ vs 49.7％,P ＜ 0.001).Higher levels of PG Ⅱ (15.9 μg/L and 13.9 μg/L vS 11.5 μg/l,P ＜ 0.001) and lower PG Ⅰ /PG Ⅱ ratio (5.4 and 4.6 vs 8.4,P ＜ 0.001) were found in patients with gastric cancer or gastric atrophy compared to healthy controls,whereas no correlation was found between the plasma PG Ⅰ concentration and risk of gastric cancer (P =0.537).In addition,multivariate logistic analysis indicated that H.pylori infection and atrophic gastritis were independent risk factors for gastric cancer.Lower plasma PG Ⅰ/PG Ⅱ ratio was associated with higher risks of atrophy and gastric cancer.Furthermore,plasma PG Ⅱ level significantly correlated with H.pyloriinfected gastric cancer.CONCLUSION:Serum PG Ⅱ concentration and PG Ⅰ/PG Ⅱ ratio are potential biomarkers for H.pyloriinfected gastric disease.PG Ⅱ is independently associated with risk of gastric cancer.

Gastric cancerPepsinogensHelicobacter pyloriGastric atrophyScreening

Xue-Yuan Cao、Zhi-Fang Jia、Mei-Shan Jin、Dong-Hui Cao、Fei Kong、Jian Suo、Jing Jiang

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Department of Gastrointestinal Surgery, Jilin University First Hospital, Changchun 130021, Jilin Province, China

Division of Clinical Epidemiology, Jilin University First Hospital,Changchun 130021, Jilin Province, China

Division of Pathology, Jilin University First Hospital, Changchun 130021, Jilin Province, China

国家自然科学基金国家自然科学基金

3097247681072369

2012

10.3748/wjg.v18.i48.7357

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(48)
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