Predictive value of KL-6 in serum for 28-day death in patients with acute paraquat poi-soning
Objective To investigate the value of the expression levels of KL-6 in serum at different time points in the evalua-tion of 28-day death in patients with acute paraquat poisoning.Methods Seventy-two patients with acute paraquat poisoning admitted to the 960th Hospital of PLA Joint Logistics Support Force from December 2015 to December 2021 were selected.The expression of KL-6 at admission,KL-6(6h),KL-6(24h)in serum,arterial blood gas and biochemical indexes were measured.The correlation be-tween serological indexes of 3 time nodes was analyzed.The influencing factors that affected the outcome were analyzed by logistics re-gression analysis.The work characteristic curves(ROC curves)of KL-6 at admission,KL-6(6h),KL-6(24 h)in serum were drawn and the area under the curve(AUC)was compared.Results Toxic dose of patients[survival group(58.5±13.2)mg/kg vs death group(155.9±20.5)mg/kg)]and urinary paraquat concentration[survival group(34.7±40.1)μg/mL vs death group(343.6±300.9)μg/mL]were significantly associated with death(P<0.05).Serum KL-6 at 6 h after admission(887.0±39.7 vs 1034.2±33.1 U/mL)and 24 h(1223.0±74.4 vs 1945.3±80.7 U/mL)had predictive value on 28 d death in patients with acute paraquat poisoning.The AUC of serum KL-6 at 24 h after admission was greater than that at 6 h after admission(0.912 vs 0.700,P<0.05).Conclusions The expression of KL-6(6h)and KL-6(24h)in serum is helpful in the early prediction of 28-day death in patients with acute paraquat poisoning,and the predictive ability of serum KL-6 at 24 h after admission is the best.
国家科技期刊平台
NSTL
万方数据
维普
