Analysis of serum vitamin levels and its influencing factors in patients with type 2 diabetes mellitus
Objective To analyze the levels of serum vitamins and its influencing factors in patients with type 2 diabetes mellitus(T2DM).Methods A total of 252 T2DM patients(diabetes group)and 228 non-diabetic individuals(control group)were selected from the Aerospace Center Hospital from July 2020 to June 2022.The levels of vitamins A,B1,B6,B9,B12,C,D,and E were compared between the two groups.The comparison of means between the two groups was conducted using an independent samples t-test,and multiple linear regres-sion equations were used to analyze the factors affecting the vitamins in the diabetes group,including gender,age,body mass index(BMI),glycated hemoglobin(HbA1c),and complications.Results There was no statistical difference between the diabetes group and the control group in gender and age composition.BMI,fasting blood glucose and HbA1c in the diabetes group were higher than those in the control group,and the levels of vitamin B1,B6,B9,B12,and C were lower than those in the control group,with statistical significance(P<0.05).The main factors affecting vitamin A in diabetic patients were gender(β=-0.1,95%CI:-0.2,0.0;P=0.03).The main factors affecting vitamin B9 were age 50-70 years(β=-0.9,95%CI:-4.5,-0.6;P=0.03)and BMI>28(β=-2.3,95%CI:-4.3,-0.4;P=0.02).The main factors affecting vitamin B12 were gender(β=37.7,95%CI:0.1,75.6;P=0.05).The main factors affecting vitamin C were gender(β=-2.4,95%CI:-4.5,-0.4;P=0.02),BMI>28(β=4.4,95%CI:1.3,7.5;P=0.01),HbA1c>10%(β=-3.3,95%CI:-6.2,-0.4;P=0.02),DR(β=0.9,95%CI:0.2,3.1;P=0.02),DKD(β=1.5,95%CI:1.1,3.6;P=0.03),and DPN(β=1.2,95%CI:1.0,3.4;P=0.05).The main factors affecting vitamin D were age 50-70 years(β=-6.4,95%CI:-12.9,0.1;P=0.05),HbA1c 7.0-10.0%(β=7.4,95%CI:1.7,13.1;P=0.01),and HbA1c>10%(β=0.3,95%CI:0.1,4.9;P=0.02).Conclusions Multi-vita-min metabolism disorder exists in patients with T2DM,vitamin level is related to various clinical factors,and individualized vitamin supple-mentation programs should be developed according to different clinical features.
type 2 diabetesvitaminglycosylated hemoglo-bincomplication
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