Relationship between ADC value of DWI examination and prognosis of pancreatic cancer patients with liver metastasis
Objective To explore the correlation between the apparent diffusion coefficient(ADC)value of diffusion weighted imaging(DWI)and the prognosis of of pancreatic cancer patients with liver metastasis.Methods A retrospective analysis was made on 96 patients with pancreatic cancer with liver metastasis confirmed by pathology in Anqing Hospital of PLA Navy from October 2019 to January 2022,and all the patients were treated with conventional MRI combined with enhanced scanning.The relevant data of the patients were collected,the ADC value of the patients'DWI was analyzed,and the patients were followed up for 12 months.Based on the survival status of the patients,they were divided into survival group(n=63)and death group(n=33),and multivariate logistic regression analysis was used to analyze the independent influencing factors that affected the treatment prognosis of the patients.Results Univariate analysis showed that there were statistical differences in age,maximum diameter of pancreatic tumor,diameter of liver metastases,number of liver metastases,lymph node metastasis,tumor differentiation,Alb and ADC values between the two groups(P<0.05),while there was no significant difference in gender,BMI,tumor location,nerve invasion,Hb,or PLT between the two groups(P>0.05).The results of multivariate analysis showed that the number of liver metastases[OR=2.702,95％CI(1.340,5.450)],vascular invasion[OR=1.906,95％CI(1.052,3.452)],tumor differentiation[OR=1.269,95％CL(1.025,1.571)]and ADC value[OR=0.422,95％CI(0.216,0.824)]were independent influencing factors on the prognosis of patients with pancre-atic cancer with liver metastasis(P<0.05),in which the ADC value was an independent protective factor,and the rest were independ-ent risk factors.Conclusions The number of liver metastases,lymph node metastasis,degree of tumor differentiation and ADC value are independent factors for the prognosis of pancreatic cancer patients with liver metastases.Clinical treatment plans can be adjusted and improved according to the corresponding situation.
pancreatic cancer with liver metastasisgadopentetate-enhanced magnetic resonance imagingapparent diffusion coefficientprognosis
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