Comparison of clinical outcomes between multi-cycle accumulative embryo transfer and non-accumulative embryo transfer in patients with diminished ovarian reserve
Objective To investigate the clinical outcomes in vitro fertilization-embryo transfer(IVF-ET)in patients with di-minished ovarian reserve(DOR)after multi-cycle cumulative and non-cumulative embryo transfer strategies.Methods Clinical data of 174 patients with DOR who underwent IVF-ET treatment in the Department of Human Reproductive Medicine,Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University from January 2019 to December 2022 were retrospectively analyzed.All the included patients had completed all embryo transfer and final follow-up.Basic endocrine,anti-mullerian hormone levels and sinus follicle counts of the patients were collected,and relevant clinical data such as ovarian response parameters and pregnancy outcomes af-ter ovulation induction therapy were recorded.The clinical outcomes of multi-cycle cumulative embryo transfer(cumulative group)and non-cumulative embryo transfer(non-cumulative group)were compared.Results No statistically significant differences were found in terms of cumulative pregnancy rate(35.24%vs.27.54%),early abortion rate(32.43%vs.26.32%),and cumulative live birth rate(21.90%vs.18.84%)between the two groups of DOR patients with multiple-cycle cumulative embryo transfer and non-cumula-tive embryo transfer(P>0.05).logistic regression analysis was performed after taking into account multiple factors such as transplanta-tion strategy,BMI,age of first egg retrieval,AMH,number of embryo transfer,number of high-quality embryo transfer,and cumula-tive number of eggs obtained,and two different embryo transfer strategies(OR=1.522,95%CI 0.608-3.814)had no significant im-pact on live birth(P>0.05).Conclusions For patients with DOR,cumulative embryo transfer after multiple cycles of repeated egg retrieval can not improve the cumulative pregnancy rate and live birth rate.
diminished ovarian reservecumulative embryo transfercumulative live birth rate in multiple cycles
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