Application of low-dose esketamine in painless gastroscopy in obese patients
Objective To investigate the efficacy and safety of low-dose esketamine in painless diagnosis in obese patients.Methods A total of 120 obese patients undergoing painless gastroscopy in General Hospital of Western Theater Command from Sep-tember 2021 to June 2022 were randomly divided into two groups,with 60 cases in each group.Group A was given esketamine 0.2 mg/kg,group B was given sufentanil 0.1 μg/kg before operation,and then propofol 1-2 mg/kg was given.Heart rate(HR),mean arterial pressure(MAP)and oxygen saturation(SpO2)were compared between the two groups before anesthesia(T1),at the time of gastroscopy insertion(T2),at the end of surgery(T3),and 10 minutes after operation.Respiratory rate(RR),the number of cases of intraoperative cough,body movement,operation stop and application of viable vessels were recorded.The operation time,awakening time and propofol dosage of the two groups were recorded.The number of postoperative nausea,vomiting,delirium and the evaluation by the operator on the effect of anesthesia were also recorded.Results HR,MAP,RR and SpO2 of group B at T2 and T3 were significantly lower than those at T1,and were significant lower than those of group B(P<0.05).The cases of intraoperative cough,body movement,operation stop and use of vasoactive drugs in group A were significantly lower than those in group B(P<0.05).The dosage of propofol in group A was significantly less than that in group B.The operation time of group A was shorter than that of group B;the number of operators'good evaluation cases was higher than that of group B(P<0.05).There were no significant differences in recovery time,postoperative nausea and vomiting or deliration cases between the two groups(P>0.05).Conclusions Low-dose esketamine used in the gastroscopy of obese patients is more safe and effective,which is characterized by more stable circulation,less respiratory depression and more satisfactory anesthetic effect.
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