Clinical research of PRP combined with autologous bone grafting in treatment of bone de-fect
Objective To evaluate the therapeutic effect of platelet-rich plasma(PRP)combined with autologous bone graft-ing in the treatment of bone defect and its influence on bone repair.Methods Sixty patients with bone defect admitted to Characteris-tics Medical Center of PLA Rocket Army from January 2023 to December 2023 were selected as the research subjects,and were divided into two groups according to the random number table method,the experimental group(30 cases)and the control group(30 cases).The experimental group was treated with PRP combined with autologous bone grafting,while the control group was treated with simple autologous bone grafting.The two groups were compared in terms of bone healing time,bone healing rate,bone density,bone strength,bone morphology scoring,LEFS scoring,and VAS scoring.Multivariate linear regression and multivariate logistic regression analyses were used to identify factors influencing bone healing.Results The experimental group showed significantly better outcomes in terms of bone healing time,bone healing rate,bone density,bone strength,and bone morphology scoring compared with the control group,with statistically significant differences(P<0.05),and no serious postoperative complications occurred.Multivariate regression analysis in-dicated that PRP treatment was an independent influencing factor for bone healing time and bone healing rate(P<0.05).Conclusions PRP combined with autologous bone grafting is a safe,effective,and feasible treatment for bone defect,which can pro-mote the healing and repair of bone defect,improve the quality of bone healing,and enhance patients'quality of life.
platelet-rich plasmaautologous bone graftingbone defectbone repair
国家科技期刊平台
NSTL
万方数据
