Causal association between weakened grip strength and risk of venous thromboembolism in the elderly
Objective To investigate causal association between weakened grip strength and the risk of venous thromboembo-lism(VTE)in the elderly.Methods The association between weakened grip strength and the risk of VTE was analyzed using Mende-lian randomization(MR),and the causal effect was mainly assessed with inverse variance weighting(IVW).The F-statistic was cal-culated to test the stability of instrumental variables,Cochran's Q-statistic was applied to test for heterogeneity,and sensitivity and plei-otropy were assessed using weighted median,MR-Egger regression and leave-one-out methods.Results There was no causal associa-tion between weakened grip strength and the risk of VTE in the elderly(OR:1.001,95%CI:0.997-1.005,P=0.524).In a fur-ther analysis of deep vein thrombosis(DVT)and pulmonary embolism(PE),similarly no causal association was found between weak-ened grip strength and the risk of DVT(OR:1.002,95%CI:0.999-1.006,P=0.254)and PE(OR:0.894,95%CI:0.700-1.141,P=0.368)in the elderly.Conclusions There is no causal association between weakened grip strength and the risk of VTE in the elderly.
the elderlymendelian randomizationgrip strengthvenous thromboembolism
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