Relationship between high mobility group protein B1 and infection degree in patients with respiratory failure and pulmonary infection and its prognostic value
Objective To investigate the relationship between high mobility group protein B1(HMGB1)and the degree of in-fection in patients with respiratory failure(RF)and pulmonary infection(PI)and its prognostic value.Methods A total of 142 patients with RF with PI admitted to the 983rd Hospital of PLA Joint Logistics Support Force from March 2020 to March 2023 were selected.Clin-ical pulmonary infection score(CPIS)was used to evaluate the infection degree of the patients.The patients were divided into mild infec-tion group(n=79)and severe infection group(n=63),and HMGB1 levels were detected.Pearson correlation coefficient was used to analyze the relationship between HMGB1 and infection degree in RF patients with lung infection.Patients were divided into poor prognosis group and good prognosis group according to their survival condition,and HMGB1 levels of the patients with different prognosis were ana-lyzed.Clinical data of the patients were collected,and multivariate logistic regression model was used to analyze the factors affecting the prognosis of RF patients with PI.The predictive value of HMGB1 in RF patients with PI was analyzed by receiver operating characteristic(ROC)curve.Results Among the 142 patients,63 cases were severely infected,79 cases were mildly infected,and the severe infection rate was 44.37%.HMGB1 level and CPIS score in severe infection group were higher than those in mild infection group(P<0.05).The results of Pearson analysis showed that HMGB1 was positively correlated with CPIS score(r=0.586,P<0.05).The mechanical ventila-tion time,hospital stay and FBG levels in the poor prognosis group were higher than those in the good prognosis group(P<0.05).Logis-tic regression analysis showed that long mechanical ventilation time and high levels of FBG and HbAlc were risk factors for poor prognosis in RF patients with PI(P<0.05,OR>1).ROC analysis results showed that the sensitivity and specificity of HMGB1 in predicting poor prognosis of RF patients with pulmonary infection were 90.38%and 81.11%respectively,and the area under the curve(AUC)value(95%CI)was 0.804(0.729-0.866).Conclusions HMGB1 is closely related to the degree of infection in RF patients with lung infec-tion.The high level of HMGB1 is a risk factor for the poor prognosis of RF patients with lung infection,and it is of good value in predic-ting the poor prognosis of RF patients with lung infection.
respiratory failurelung infectiondegree of in-fectionforecast
国家科技期刊平台
NSTL
万方数据
