Relationship between thyroid hormone levels and frailty in elderly community members
Objective To analyze the relationship between thyroid hormones(THs),frailty and the five components of frailty phenotype(fatigue,resistance,walking ability,number of illnesses,and weight loss)in the elderly.Methods Cross-sectional study with 487 community-dwelling elderly residents aged≥80 years was conducted.A clear diagnosis of frailty was made based on the FRAIL scale(fatigue,resistance,walking,disease,and weight loss),and positive scores were recorded for each frailty subdomain.Demographic information(age,sex,marital status and education),comorbidities,and details of the participants'lifestyles were also recorded.Laboratory tests were performed to determine serum THs,including free triiodothyronine(fT3),triiodothyronine(T3),free thyroxine(fT4),and thyroxine(T4),and thyroid stimulating hormone(TSH)levels.logistic regression of the data was performed to screen out potential risk factors for frailty and its subdomains.Results Of the 487 subjects enrolled,60(12.23%)were diagnosed with subclinical hypothyroidism,and 110(22.59%)had a positive frailty score.Logistic regression analysis adjusted for all potential confounders showed that frailty was significantly associated with serum TSH concentration(OR:1.06),fT3 concentration(OR:0.54),and subclinical hypothyroidism(OR:2.18).The study showed no association between fT4 and frailty,whereas fT3/fT4 was associated with frailty.Conclusions Subclinical hypothyroidism,higher TSH levels,lower fT3 levels,and lower fT3/fT4 ratio are all associated with frailty as assessed by the FRAIL scale in community-dwelling elderly.Future longitudinal studies are needed to continue to deter-mine the association between thyroid dysfunction and frailty in the elderly.
国家科技期刊平台
NSTL
万方数据
