Correlation between serum decoy receptor 3 and airflow restriction,quality of life,and exacerbations within 1 year in patients with moderate to severe stable COPD
Objective To investigate the serum Decoy Receptor 3(DcR3)level in patients with chronic obstructive pulmona-ry disease(COPD)and to investigate the correlation of DcR3 with airflow restriction,quality of life and acute exacerbations within 1 year.Methods From August 2021 to August 2022,81 patients with moderate to severe COPD were included as study subjects.Serum DcR3 levels were measured by enzyme-linked immunosorbent assay,and the correlation of serum DcR3 with airflow restriction and quality of life was analyzed by Spearman correlation analysis.The clinical factors influencing acute exacerbations within 1 year were an-alyzed by binary Logistic regression,and the clinical value of serum DcR3 in predicting acute exacerbations within 1 year was analyzed by receiver operating characteristic(ROC)curve.Results Compared with the serum DcR3≥2.45 ng/ml(median)group,the baso-phil count in the serum DcR3<2.45 ng/ml group significantly increased(P<0.05),and the number of acute exacerbation and hospi-talizations within 1 year significantly decreased(P<0.05).Serum DcR3 was negatively correlated with forced expiratory volume in the first second(FEV1)(r=-0.389),FEV1/forced vital capacity(FVC)(r=-0.610),diffusing capacity of the lungs for carbon mon-oxide(r=-0.611),and inspiratory volume(IC)/total lung ratio(TLC)(r=-0.862),all P<0.05.There was a positive correlation between serum DcR3 and COPD assessment test(CAT)(r=0.638),visual analogue scale(VAS)-cough(r=0.282),VAS-sputum(r=0.269)and VAS-purulent sputum(r=0.237)scores,all P<0.05.Interleukin(IL)-6 was negatively correlated with 75%of the maximum expiratory flow rate(r=-0.481),and C-reactive protein(CRP)was positively correlated with CAT score(r=0.521),both P<0.05.By binary logistic regression,serum DcR3 was independently correlated with acute exacerbations of COPD within one year(P<0.05).The area under the curve of serum DcR3 in predicting acute exacerbations in COPD patients within 1 year was[0.788(95%CI:0.688～0.888)],and the sensitivity(0.689)and specificity(0.833)were the highest when serum DcR3≥2.435 ng/ml.Conclusions Serum DcR3 is associated with airflow restriction,quality of life,disease severity and acute onset within 1 year in COPD patients,and serum DcR3 level has potential as a marker of patho-genesis of COPD patients.
chronic obstructive pulmonary diseasedecoy receptor 3airflow restrictionquality of lifeacute exacerbation
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