儿童重症监护病房与呼吸机相关的肺炎危险因素Meta分析
Meta-analysis of risk factors for ventilator-associated pneumonia in pediatric intensive care units
林伟 1赵芳珉 1赵祝英 1张杰2
作者信息
- 1. 610011 成都,西部战区空军医院:疾病预防控制科
- 2. 610011 成都,西部战区空军医院:耳鼻喉科
- 折叠
摘要
目的 系统评价儿童重症监护病房(PICU)中与呼吸机相关的肺炎(VAP)危险因素.方法 通过计算机检索中国知网、维普数据库、万方数据库、PubMed、Embase、The Cochrane library、CBM等中英文数据库,筛选关于PICU中VAP危险因素的文献.使用RevMan5.4 和stata15.0 进行meta分析.结果 纳入14 篇文献,包括中文9 篇,英文5 篇,研究对象总数为5242 例.综合评价了 13 个可能的危险因素,并根据研究区域进行亚组分析.结果 显示,年龄<1 岁、患有呼吸系统疾病、反复插管、肠外营养、支气管镜检查,使用糖皮质激素、镇静剂、抑酸药是PICU内发生VAP的危险因素(P<0.05).亚组分析结果显示,在中国各地,以上因素均具有统计学意义(P<0.05).结论 医护人员可参考本研究结果密切关注上述危险因素,早期识别并采取有效的防控措施,减少PICU内VAP的发生.
Abstract
Objective To systematically evaluate the risk factors for ventilator-associated pneumonia(VAP)in pediatric in-tensive care units(PICU).Methods Chinese and English databases such as CNKI,VIP,Wanfang,PubMed,Embase,The Co-chrane Library,and CBM,were searched for literature on VAP risk factors in PICU.Meta-analysis was performed using RevMan5.4 and stata15.0.Results A total of 14 articles were included,including 9 in Chinese and 5 in English,involving 5,242 patients.Thir-teen potential risk factors were comprehensively evaluated,and subgroup analysis were performed based on the study area.The results showed that age<1 year,respiratory disease,repeated intubation,parenteral nutrition,bronchoscopy,use of glucocorticoids,sedatives and acid suppressants were risk factors for VAP in PICU(P<0.05).Subgroup analysis indicated that these factors were statistically significant across different regions of China(P<0.05).Conclusions Medical staff should closely monitor the identified risk factors,utilize early detection strategies,and implement effective preventive measures to reduce the occurrence of VAP in PICU.
关键词
儿童/重症监护/呼吸机相关性肺炎/危险因素/meta分析Key words
children/intensive care/ventilator-associated pneumonia/risk factors/meta-analysis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据